Qiu Ziye, Chen Sixue, Feng Ningning, Li Wenhao, Ma Yukun, Zhou Shibo, Jiang Guozheng, Zhou Yishu, Yu Xing, Xiong Yang
Department of Orthopedics Dongzhimen Hospital Afliated to Beijing University of Chinese Medicine Beijing China.
Department of Orthopedics, Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing China.
JOR Spine. 2025 Jan 23;8(1):e70038. doi: 10.1002/jsp2.70038. eCollection 2025 Mar.
Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc degeneration (IDD) are most common degenerative factors. However, whether there is a correlation between changes in vertebral bone mass and IDD remains unclear. In this study, based on magnetic resonance imaging (MRI), Pfirrmann method was used to grade cervical disc degeneration, and vertebral bone quality (VBQ) was measured. The correlation between VBQ and IDD was analyzed, and its potential mechanism was discussed as well.
From June 2019 to June 2023, clinical data of patients undergoing surgical treatment for cervical degenerative disc diseases (CDDD) in our department were retrospectively analyzed. Preoperative MRI was collected, the degree of IDD was assessed by Pfirrmann grading, and VBQ was measured by T1-weighted image of MRI. With VBQ score = 3.08 as the threshold, Spearman correlation analysis was used to quantified the correlation between IDD grade and VBQ, and multiple ordered Logistic regression analysis was used to evaluate the effect of VBQ on IDD grade.
The preoperative MRI data of 94 patients (male, 42; female, 52) with CDDD were collected. Spearman correlation analysis: When VBQ score ≤ 3.08, the IDD grade was negatively correlated with VBQ ( < 0.05, = -0.153). When VBQ score > 3.08, the IDD grade was positively correlated with VBQ ( < 0.05, = 0.306). Multiple ordered Logistic regression analysis: When VBQ score ≤ 3.08, the effect of VBQ on IDD was negatively correlated ( < 0.05, = -0.597). When VBQ score > 3.08, the effect of VBQ on IDD was positively correlated ( < 0.05, = 0.986).
Either excessive increased or decreased VBQ in the cervical spine may accelerate the progression of IDD. The reason may be that both abnormal interference from the VBQ may imbalance the cervical spinal biomechanics and compromise the absorption of nutrients in the disc, thus accelerating the IDD. Therefore, cervical VBQ may have a bidirectional effect on IDD.
颈椎退变涉及多种病理生理变化。椎体骨质流失、椎体硬化增生和椎间盘退变（IDD）是最常见的退变因素。然而，椎体骨量变化与IDD之间是否存在相关性仍不清楚。在本研究中，基于磁共振成像（MRI），采用Pfirrmann法对颈椎间盘退变进行分级，并测量椎体骨质量（VBQ）。分析VBQ与IDD之间的相关性，并探讨其潜在机制。
回顾性分析2019年6月至2023年6月在我科接受颈椎间盘退变疾病（CDDD）手术治疗患者的临床资料。收集术前MRI，采用Pfirrmann分级评估IDD程度，通过MRI的T1加权图像测量VBQ。以VBQ评分=3.08为阈值，采用Spearman相关分析量化IDD分级与VBQ之间的相关性，采用多有序Logistic回归分析评估VBQ对IDD分级的影响。
收集了94例（男性42例，女性52例）CDDD患者的术前MRI数据。Spearman相关分析：当VBQ评分≤3.08时，IDD分级与VBQ呈负相关（<0.05，= -0.1
