Chen Ang, Feng Shangyong, Lai Lijuan, Yan Caifeng
Department of Endocrinology, Northern Jiangsu People's Hospital, The First Clinical College of Dalian Medical University, Yangzhou 225001, Jiangsu, China.
Bone Rep. 2023 Aug 26;19:101711. doi: 10.1016/j.bonr.2023.101711. eCollection 2023 Dec.
Osteoporosis is the most common skeletal disease in humans. Early onset of osteoporosis is usually asymptomatic, so early diagnosis is critical. The purpose of this study was to analyze the value of MRI-based VBQ scores for evaluating osteoporosis.
We searched PubMed, Embase, the Cochrane Library databases, Web of Science, and some Chinese electronic databases for published articles and the ClinicalTrials.gov site for completed but unpublished studies on evaluating the value of MRI-based VBQ scores for evaluating osteoporosis. We calculated the summarized sensitivity, specificity, the ROC curve (AUC) values and their 95% confidence intervals (CIs) using MetaDiSc 1.4 software and STATA.
Our study included 8 studies involving 999 patients of which 660 patients were diagnosed with osteopenia/osteoporosis, and 339 patients were identified as having normal BMD. The pooled sensitivity was 0.809 (95% CI, 0.777-0.838, = 78.8%), the pooled specificity was 0.640 (95% CI, 0.587-0.691, = 85.9%), and the pooled AUC was 0.8375.
MRI-based VBQ scores provided high sensitivity and moderate specificity in detecting osteoporosis. Opportunistic use of VBQ scores could be considered, e.g. before lumbar spine surgery.
CRD42022377024.
骨质疏松症是人类最常见的骨骼疾病。骨质疏松症早期通常无症状，因此早期诊断至关重要。本研究的目的是分析基于MRI的椎体骨定量（VBQ）评分在评估骨质疏松症中的价值。
我们检索了PubMed、Embase、Cochrane图书馆数据库、Web of Science以及一些中文电子数据库中的已发表文章，并检索了ClinicalTrials.gov网站上关于评估基于MRI的VBQ评分在评估骨质疏松症中价值的已完成但未发表的研究。我们使用MetaDiSc 1.4软件和STATA计算汇总敏感性、特异性、受试者工作特征曲线（ROC曲线）（AUC）值及其95%置信区间（CIs）。
我们的研究纳入了8项研究，涉及999例患者，其中660例被诊断为骨质减少/骨质疏松症，339例被确定为骨密度正常。汇总敏感性为0.809（95%CI，0.777-0.838， = 78.8%），汇总特异性为0.640（95%CI，0.587-0.691， = 85.9%），汇总AUC为0.8375。
基于MRI的VBQ评分在检测骨质疏松症方面具有高敏感性和中等特异性。可以考虑适时使用VBQ评分，例如在腰椎手术前。
CRD42022377024。
