Department of Radiology and Institute of Medical Functional and Molecular Imaging, Huashan Hospital, Fudan University, Shanghai, China.
MR Collaborations, Siemens Healthineers Ltd., Shanghai, China.
J Magn Reson Imaging. 2022 May;55(5):1536-1546. doi: 10.1002/jmri.27959. Epub 2021 Oct 19.
The relationship between osteoporosis and intervertebral disc (IVD) degeneration remains controversial. Novel quantitative Dixon (Q-Dixon) and GRAPPATINI T2 mapping techniques have shown potential for evaluating the biochemical components of the spine.
To investigate the correlation of osteoporosis with IVD degeneration in postmenopausal women.
Prospective.
A total of 105 postmenopausal females (mean age, 65 years; mean body mass index, 26 kg/m ).
FIELD STRENGTH/SEQUENCE: 3 T; sagittal; 6-echo Q-Dixon, multiecho spin-echo GRAPPATINI T2 mapping, turbo spin echo (TSE) T1-weighted and TSE T2-weighted sequences.
The subjects were divided into normal (N = 47), osteopenia (N = 28), and osteoporosis (N = 30) groups according to quantitative computed tomography examination. The Pfirrmann grade of each IVD was obtained. Region of interest analysis was performed separately by two radiologists (X.L., with 10 years of experience, and S.C., with 20 years of experience) on a fat fraction map and T2 map to calculate the bone marrow fat fraction (BMFF) from the L1 to L5 vertebrae and the T2 values of each adjacent IVD separately.
One-way analysis of variance, post-hoc comparisons, and Kruskal-Wallis H tests were performed to evaluate the differences in the magnetic resonance imaging parameters between the groups. The relationships between BMFF and the IVD features were analyzed using the Spearman correlation analysis and linear regression models.
There were significant differences in BMFF among the three groups. The osteoporosis group had higher BMFF values (64.5 ± 5.9%). No significant correlation was found between BMFF and Pfirrmann grade (r = 0.251, P = 0.06). BMFF was significantly negatively correlated with the T2 of the adjacent IVD from L1 to L3 (r = -0.731; r = -0.637; r = -0.547), while significant weak correlations were found at the L4 to L5 levels (r = -0.337; r = -0.278).
This study demonstrated that osteoporosis is associated with IVD degeneration.
2 TECHNICAL EFFICACY: Stage 4.
骨质疏松症与椎间盘（IVD）退变之间的关系仍存在争议。新型定量 Dixon（Q-Dixon）和 GRAPPATINI T2 映射技术已显示出评估脊柱生化成分的潜力。
研究绝经后女性骨质疏松症与 IVD 退变的相关性。
前瞻性。
共 105 名绝经后女性（平均年龄 65 岁；平均体重指数 26kg/m²）。
磁场强度/序列：3T；矢状位；6 回波 Q-Dixon、多回波自旋回波 GRAPPATINI T2 映射、涡轮自旋回波（TSE）T1 加权和 TSE T2 加权序列。
根据定量计算机断层扫描检查，将受试者分为正常（N=47）、骨量减少（N=28）和骨质疏松（N=30）组。获得每个 IVD 的 Pfirrmann 分级。由两位放射科医生（X.L.，具有 10 年经验，和 S.C.，具有 20 年经验）分别在脂肪分数图和 T2 图上对感兴趣区域进行分析，以计算 L1 到 L5 椎体的骨髓脂肪分数（BMFF）和每个相邻 IVD 的 T2 值。
采用单因素方差分析、事后比较和 Kruskal-Wallis H 检验评估组间磁共振成像参数的差异。采用 Spearman 相关分析和线性回归模型分析 BMFF 与 IVD 特征的关系。
三组间的 BMFF 存在显著差异。骨质疏松组的 BMFF 值较高（64.5±5.9%）。BMFF 与 Pfirrmann 分级之间无显著相关性（r=0.251，P=0.06）。BMFF 与 L1 到 L3 水平的相邻 IVD 的 T2 值呈显著负相关（r=-0.731；r=-0.637；r=-0.547），而在 L4 到 L5 水平则存在显著弱相关（r=-0.337；r=-0.278）。
本研究表明骨质疏松症与 IVD 退变有关。
2 技术功效：4 级。
