Adil Mohammad, Amin Syed Suhail
Department of Dermatology, Era's Lucknow Medical College, Era's University, Lucknow, Uttar Pradesh, India.
Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Indian Dermatol Online J. 2024 Dec 11;16(1):123-128. doi: 10.4103/idoj.idoj_474_24. eCollection 2025 Jan-Feb.
Nail psoriasis is a relatively unexplored clinical feature in the Indian population. Its correlation with cutaneous, musculoskeletal, and serological manifestations was analyzed.
This study included 45 patients with clinically evident nail psoriasis. Clinical characteristics, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Nail Psoriasis Quality of Life Index 10 (NPQ10) scores and serological markers, Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), and Rheumatoid Arthritis factor (RA factor) were documented, calculated, and assessed to study their correlation.
Mean age was 35.36 ± 13.26 years. Mean NAPSI and NPQ10 were 41.96 ± 29.38 and 5.44 ± 5.31, respectively. Common nail findings were onycholysis (80%), subungual hyperkeratosis (75.5%), and pitting (62.2%). Joint involvement was seen in 31.11% of patients. Positive associations of NAPSI with duration of illness ( < 0.001, β = 0.57) and PASI scores ( < 0.001, β = 0.56) were observed. NPQ10 demonstrated associations with NAPSI ( < 0.001, β = 0.83) and PASI ( = 0.001, β = 0.83). Elevated ESR and CRP levels were associated with higher NAPSI scores ( < 0.001, β = 0.55, and = 0.003, β = 0.43, respectively). Furthermore, duration of illness, NAPSI, and NPQ10 scores were positively correlated with joint involvement ( < 0.05).
A strong correlation between nail psoriasis severity, disease duration, skin involvement, and nail-specific quality of life was observed. Furthermore, severe nail psoriasis was linked to a higher likelihood of joint involvement and elevated serological markers. These findings emphasize the importance of integrated treatment strategies for affected patients.
在印度人群中，指甲银屑病是一个相对未被充分研究的临床特征。分析了其与皮肤、肌肉骨骼及血清学表现的相关性。
本研究纳入45例临床诊断为指甲银屑病的患者。记录、计算并评估临床特征、银屑病面积和严重程度指数（PASI）、指甲银屑病严重程度指数（NAPSI）、指甲银屑病生活质量指数10（NPQ10）评分以及血清学标志物红细胞沉降率（ESR）、C反应蛋白（CRP）和类风湿因子（RA因子），以研究它们之间的相关性。
平均年龄为35.36±13.26岁。平均NAPSI和NPQ10分别为41.96±29.38和5.44±5.31。常见的指甲表现为甲剥离（80%）、甲下过度角化（75.5%）和点状凹陷（62.2%）。31.11%的患者出现关节受累。观察到NAPSI与病程（<0.001，β=0.57）和PASI评分（<0.001，β=0.56）呈正相关。NPQ10与NAPSI（<0.001，β=0.83）和PASI（=0.001，β=0.83）相关。ESR和CRP水平升高与较高的NAPSI评分相关（分别为<0.001，β=0.55和=0.003，β=0.43）。此外，病程、NAPSI和NPQ10评分与关节受累呈正相关（<0.05）。
观察到指甲银屑病严重程度、病程、皮肤受累及指甲特异性生活质量之间存在密切相关性。此外，严重的指甲银屑病与关节受累可能性增加及血清学标志物升高有关。这些发现强调了针对受影响患者采取综合治疗策略的重要性。
