Bhat Yasmeen Jabeen, Ul Islam Mohd Shurjeel, Errichetti Enzo
Dermatology, Venereology and Leprosy, Government Medical College Srinagar, Jammu and Kashmir, India.
Department of Experimental and Clinical Medicine, DISM, Institute of Dermatology Udine, Udine, Italy.
Indian Dermatol Online J. 2024 Dec 13;16(1):25-39. doi: 10.4103/idoj.idoj_299_24. eCollection 2025 Jan-Feb.
Ultraviolet-induced fluorescence dermoscopy (UVF dermoscopy) is a novel diagnostic technique for identifying and diagnosing numerous skin tumors, inflammatory dermatoses, and infectious diseases. The ultraviolet (UV) band has a wavelength ranging from 10 to 400 nm. When intense UV radiation with shorter wavelengths strikes a target chromophore, visible light (VL) with a longer wavelength and lower energy is produced in the skin. This VL is apparent to the naked eye and is referred to as fluorescence.
The current review compares ultraviolet fluorescence dermoscopy (UVFD) and polarized dermoscopy (PD) features in various dermatological disorders.
This review was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalyses) guidelines. A comprehensive search of the literature was carried out through the PubMed and Google Scholar electronic databases from inception to 25 December 2023 using the following search terms: "UV dermoscopy" OR "ultraviolet fluorescence dermoscopy" OR "ultraviolet-induced fluorescence dermoscopy" OR "Ultraviolet-induced fluorescent dermoscopy". Titles, abstracts, and full texts were screened by two independent reviewers to select papers dealing with UVF-dermoscopy.
A total of 23 relevant articles were included in this systematic review, including a total of 313 patients. Pigmented skin tumors included 209 patients, Fordyce spot mimickers (13), scabies (57), biopsy site (20), psoriasis (3), corynebacterium infections (2), fungal infections (4), vitiligo (3), acne folliculitis (1) and glomus tumors (1). Levels of evidence (LoE) was 3 and 4 in only two included studies; the rest had a LoE of 5.
UVF dermoscopy is a new diagnostic and prognostic tool for neoplastic and non-neoplastic dermatological conditions. This is the first systematic review of its sort that compares and categorizes dermoscopic findings in UVF and polarized light in dermatological practice. As UVFD does not penetrate deeper skin layers, we observed that it is a better way to distinguish features restricted to the skin's superficial layers in neoplastic diseases. As a result, tumor-free margins and improved surgical outcomes can be achieved. More favorable outcomes for evaluation and treatment were seen with non-neoplastic conditions. Limitations included a lack of studies with a high level of evidence, control groups, and larger sample sizes.
We concluded that UVFD will improve clinical diagnosis, disease management, and outcomes. More clinical trials with larger sample sizes are recommended to better understand this novel and intriguing new diagnostic tool.
紫外线诱导荧光皮肤镜检查（UVF皮肤镜检查）是一种用于识别和诊断多种皮肤肿瘤、炎症性皮肤病及感染性疾病的新型诊断技术。紫外线（UV）波段的波长范围为10至400纳米。当波长较短的强紫外线辐射照射到目标发色团时，皮肤中会产生波长较长、能量较低的可见光（VL）。这种VL肉眼可见，被称为荧光。
本综述比较了紫外线荧光皮肤镜检查（UVFD）和偏振皮肤镜检查（PD）在各种皮肤病中的特征。
本综述按照PRISMA（系统评价和荟萃分析的首选报告项目）指南进行。通过PubMed和谷歌学术电子数据库，使用以下检索词对从数据库建立至2023年12月25日的文献进行了全面检索：“UV皮肤镜检查”或“紫外线荧光皮肤镜检查”或“紫外线诱导荧光皮肤镜检查”或“紫外线诱导荧光皮肤镜检查”。由两名独立评审员筛选标题、摘要和全文，以选择涉及UVF皮肤镜检查的论文。
本系统评价共纳入23篇相关文章，共313例患者。色素性皮肤肿瘤患者209例，福代斯斑样病变（13例），疥疮（57例），活检部位（20例），银屑病（3例），棒状杆菌感染（2例），真菌感染（4例），白癜风（3例），痤疮毛囊炎（1例）和球瘤（1例）。仅两项纳入研究的证据水平（LoE）为3级和4级；其余研究的LoE为5级。
UVF皮肤镜检查是一种用于肿瘤性和非肿瘤性皮肤病的新型诊断及预后评估工具。这是首次此类系统评价，比较并分类了皮肤科实践中UVF和偏振光下的皮肤镜检查结果。由于UVFD不会穿透更深的皮肤层，我们观察到它是区分肿瘤性疾病中局限于皮肤表层特征的更好方法。因此，可以实现无肿瘤切缘并改善手术效果。在非肿瘤性疾病中，评估和治疗效果更佳。局限性包括缺乏高质量证据的研究、对照组和更大样本量。
我们得出结论，UVFD将改善临床诊断、疾病管理及治疗效果。建议开展更多大样本量的临床试验，以更好地了解这种新颖且有趣的新型诊断工具。
