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处于化疗耐药十字路口的热休克因子1：从细胞死亡机制的当前见解到未来展望

HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms.

作者信息

Ghai Shruti, Shrestha Rejina, Su Kuo-Hui

机构信息

Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States.

出版信息

Front Cell Dev Biol. 2025 Jan 9;12:1500880. doi: 10.3389/fcell.2024.1500880. eCollection 2024.

DOI:10.3389/fcell.2024.1500880
PMID:39850800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11754285/
Abstract

Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1's role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1's function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit. In addition, we discuss emerging research implicating HSF1's roles in autophagy, apoptosis, DNA damage repair, drug efflux, and thus chemoresistance. This article highlights the significance of HSF1 in cancer chemoresistance and its potential as a target for enhancing cancer treatment efficacy.

摘要

热休克因子1（HSF1）是调节热休克反应的主要转录因子，已成为克服癌症化疗耐药性的潜在靶点。本综述全面研究了HSF1在化疗耐药中的作用及其作为癌症治疗靶点的潜力。我们探讨了调节HSF1激活的复杂机制、HSF1在促进化疗耐药中的功能，以及为获得治疗益处而操纵HSF1的策略。此外，我们还讨论了有关HSF1在自噬、细胞凋亡、DNA损伤修复、药物外排以及化疗耐药中作用的新兴研究。本文强调了HSF1在癌症化疗耐药中的重要性及其作为提高癌症治疗疗效靶点的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/f84717cb00ad/fcell-12-1500880-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/80cd1a0e0f5c/fcell-12-1500880-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/01adffe5e60c/fcell-12-1500880-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/a51ae8cb383e/fcell-12-1500880-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/f84717cb00ad/fcell-12-1500880-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/80cd1a0e0f5c/fcell-12-1500880-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/01adffe5e60c/fcell-12-1500880-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/a51ae8cb383e/fcell-12-1500880-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97fe/11754285/f84717cb00ad/fcell-12-1500880-g005.jpg

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本文引用的文献

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Advancing Immunotherapy in Pancreatic Cancer.推进胰腺癌的免疫疗法。
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The dual role of autophagy in suppressing and promoting hepatocellular carcinoma.自噬在抑制和促进肝细胞癌中的双重作用。
Front Cell Dev Biol. 2024 Oct 11;12:1472574. doi: 10.3389/fcell.2024.1472574. eCollection 2024.
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Unveiling the impact of SUMOylation at K298 site of heat shock factor 1 on glioblastoma malignant progression.揭示热休克因子 1 第 K298 位 SUMOylation 对胶质母细胞瘤恶性进展的影响。
Neoplasia. 2024 Nov;57:101055. doi: 10.1016/j.neo.2024.101055. Epub 2024 Sep 10.
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Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells.Hsp70 通过调控 AMPK 激活负向调节自噬，双重 Hsp70-自噬抑制在非小细胞肺癌细胞中诱导协同性细胞死亡。
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Bag-1-mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells.Bag-1 介导的 HSF1 磷酸化调节乳腺癌细胞热休克蛋白的表达。
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