Johnson A P, Scoper S V, Woo F L, Caldwell D R, George W J
Am J Ophthalmol. 1985 Apr 15;99(4):469-72. doi: 10.1016/0002-9394(85)90015-7.
We administered 4 g of azlocillin sodium intravenously to 24 patients scheduled to undergo elective intraocular surgery and collected specimens of serum, tears, and aqueous humor from zero to six hours after infusion for assay by high-pressure liquid chromatography. We found that azlocillin is distributed into tears and penetrates into the aqueous humor of human volunteers with noninflamed eyes after a single intravenous dose. Levels of 4.17 micrograms/ml and 4.44 micrograms/ml were achieved in tears and aqueous humor, respectively.
我们对24例计划接受择期眼内手术的患者静脉注射4克阿洛西林钠，并在输注后0至6小时采集血清、泪液和房水样本，通过高压液相色谱法进行检测。我们发现，单次静脉给药后，阿洛西林可分布到泪液中，并渗透到未发炎眼睛的人类志愿者的房水中。泪液和房水中的浓度分别达到4.17微克/毫升和4.44微克/毫升。
