Moudgil Aman D, Nehra Anil K, Moudgil Pallavi
Department of Veterinary Parasitology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125004, India.
Department of Veterinary Public Health and Epidemiology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, 125004, India.
New Microbes New Infect. 2024 Dec 31;63:101562. doi: 10.1016/j.nmni.2024.101562. eCollection 2025 Feb.
is a zoonotic tapeworm, commonly known as Asian It is an emerging sister species of with pigs as intermediate hosts. The present study aimed at genetic characterization and population structure analysis of metacestodes in slaughtered pigs in Haryana, north India.
In total, the vital organs of 253 slaughtered pigs were screened for the presence of metacestodes. The molecular identification and phylogenetics were performed targeting the mitochondrial NADH dehydrogenase subunit 1 () and cytochrome C oxidase subunit 1 () genes. The median-joining haplotype network and population structure analyses were performed with the sequences generated herein and GenBank-archived sequences for both mitochondrial signatures.
Out of 253 pigs screened, the liver of only one animal showed the presence of metacestodes. The sequences generated herein exhibited 99.60 % and 98.85 % similarity to the GenBank-archived sequences of corresponding to the and genes, respectively. Overall, 2 and 6 haplotypes for the overall data set with low nucleotide (0.00399 ± 0.00237 and 0.00095 ± 0.00042) and low haplotype (0.400 ± 0.237 and 0.131 ± 0.054) diversities were recorded for the and genes, respectively. The negative values recorded for the neutrality indices exhibited deviations from neutrality and hence, propounded recent population expansion or purifying selection or selective sweep.
The findings of the present study are of significant medical importance considering an emerging global public health threat of the neglected tapeworm
是一种人畜共患绦虫，通常称为亚洲绦虫。它是猪带绦虫的一个新兴姊妹物种，以猪作为中间宿主。本研究旨在对印度北部哈里亚纳邦屠宰猪体内的亚洲绦虫囊尾蚴进行基因特征分析和种群结构分析。
总共对253头屠宰猪的重要器官进行了亚洲绦虫囊尾蚴检测。针对线粒体烟酰胺腺嘌呤二核苷酸脱氢酶亚基1（）和细胞色素C氧化酶亚基1（）基因进行分子鉴定和系统发育分析。利用本文生成的序列以及GenBank存档的这两个线粒体特征序列进行了中介连接单倍型网络和种群结构分析。
在253头被检测的猪中，只有一头猪的肝脏发现有亚洲绦虫囊尾蚴。本文生成的序列与GenBank存档的对应于和基因的亚洲绦虫序列分别显示出99.60%和98.85%的相似性。总体而言，对于整个数据集，和基因分别记录到2个和6个单倍型，核苷酸多样性较低（分别为0.00399±0.00237和0.00095±0.00042），单倍型多样性也较低（分别为0.400±0.237和0.131±0.054）。中性指数的负值表明偏离了中性，因此表明近期种群扩张或纯化选择或选择性清除。
考虑到这种被忽视的绦虫对全球公共卫生构成的新威胁，本研究结果具有重要的医学意义。
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