Schultz R T, Pitha J V, McDonald T, Debault L E
Am J Pathol. 1985 Apr;119(1):138-50.
Definite lesions of arteriolar capillaries have been demonstrated in early amyloid lesions of mice. Pathologic changes include multiple endothelial gaps, the loss of an identifiable basal lamina, variable degrees of endothelial alteration, and the presence of the developing amyloid lesions surrounding the affected vessels. Despite these changes, the vessels remain functional part of the local microcirculation as demonstrated by intravascular injection of electron dense markers. These structural changes of arteriolar capillaries explain the presence of circulating plasma as a constant and major component of the early amyloid lesions in these animals and on this basis may determine the time of onset and site of formation of the lesions. The vascular injury appears to be caused by immunologic reactions to injected foreign antigens which gain a close relation to the structures of these vessels.
在小鼠早期淀粉样病变中已证实存在小动脉毛细血管的明确病变。病理变化包括多个内皮间隙、可识别的基膜缺失、不同程度的内皮改变，以及受影响血管周围正在形成的淀粉样病变。尽管有这些变化，但通过血管内注射电子致密标记物表明，这些血管仍是局部微循环的功能组成部分。小动脉毛细血管的这些结构变化解释了循环血浆作为这些动物早期淀粉样病变的持续且主要成分的存在，并且在此基础上可能决定病变的起始时间和形成部位。血管损伤似乎是由对注射的外来抗原的免疫反应引起的，这些抗原与这些血管的结构密切相关。
