Microelectronics and Semiconductor Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.
Bioengineering Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.
Biosensors (Basel). 2024 Jul 9;14(7):335. doi: 10.3390/bios14070335.
The non-invasive brain sensing modulation technology field is experiencing rapid development, with new techniques constantly emerging. This study delves into the field of non-invasive brain neuromodulation, a safer and potentially effective approach for treating a spectrum of neurological and psychiatric disorders. Unlike traditional deep brain stimulation (DBS) surgery, non-invasive techniques employ ultrasound, electrical currents, and electromagnetic field stimulation to stimulate the brain from outside the skull, thereby eliminating surgery risks and enhancing patient comfort. This study explores the mechanisms of various modalities, including transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), highlighting their potential to address chronic pain, anxiety, Parkinson's disease, and depression. We also probe into the concept of closed-loop neuromodulation, which personalizes stimulation based on real-time brain activity. While we acknowledge the limitations of current technologies, our study concludes by proposing future research avenues to advance this rapidly evolving field with its immense potential to revolutionize neurological and psychiatric care and lay the foundation for the continuing advancement of innovative non-invasive brain sensing technologies.
非侵入式脑传感调节技术领域正在快速发展,新的技术不断涌现。本研究深入探讨了非侵入式脑神经调节领域,这是一种更安全、更有效的治疗一系列神经和精神疾病的方法。与传统的深部脑刺激(DBS)手术不同,非侵入式技术利用超声波、电流和电磁场刺激来从颅骨外部刺激大脑,从而消除手术风险并提高患者舒适度。本研究探讨了各种模式的机制,包括经颅直流电刺激(tDCS)和经颅磁刺激(TMS),强调它们在治疗慢性疼痛、焦虑、帕金森病和抑郁症方面的潜力。我们还探讨了闭环神经调节的概念,即根据实时脑活动个性化刺激。虽然我们承认当前技术的局限性,但本研究最后提出了未来的研究方向,以推进这一快速发展的领域,其具有巨大的潜力来彻底改变神经和精神保健,并为创新的非侵入式脑传感技术的持续进步奠定基础。
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