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非侵入性脑传感技术在神经紊乱调制中的应用

Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders.

机构信息

Microelectronics and Semiconductor Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.

Bioengineering Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.

出版信息

Biosensors (Basel). 2024 Jul 9;14(7):335. doi: 10.3390/bios14070335.


DOI:10.3390/bios14070335
PMID:39056611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274405/
Abstract

The non-invasive brain sensing modulation technology field is experiencing rapid development, with new techniques constantly emerging. This study delves into the field of non-invasive brain neuromodulation, a safer and potentially effective approach for treating a spectrum of neurological and psychiatric disorders. Unlike traditional deep brain stimulation (DBS) surgery, non-invasive techniques employ ultrasound, electrical currents, and electromagnetic field stimulation to stimulate the brain from outside the skull, thereby eliminating surgery risks and enhancing patient comfort. This study explores the mechanisms of various modalities, including transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), highlighting their potential to address chronic pain, anxiety, Parkinson's disease, and depression. We also probe into the concept of closed-loop neuromodulation, which personalizes stimulation based on real-time brain activity. While we acknowledge the limitations of current technologies, our study concludes by proposing future research avenues to advance this rapidly evolving field with its immense potential to revolutionize neurological and psychiatric care and lay the foundation for the continuing advancement of innovative non-invasive brain sensing technologies.

摘要

非侵入式脑传感调节技术领域正在快速发展,新的技术不断涌现。本研究深入探讨了非侵入式脑神经调节领域,这是一种更安全、更有效的治疗一系列神经和精神疾病的方法。与传统的深部脑刺激(DBS)手术不同,非侵入式技术利用超声波、电流和电磁场刺激来从颅骨外部刺激大脑,从而消除手术风险并提高患者舒适度。本研究探讨了各种模式的机制,包括经颅直流电刺激(tDCS)和经颅磁刺激(TMS),强调它们在治疗慢性疼痛、焦虑、帕金森病和抑郁症方面的潜力。我们还探讨了闭环神经调节的概念,即根据实时脑活动个性化刺激。虽然我们承认当前技术的局限性,但本研究最后提出了未来的研究方向,以推进这一快速发展的领域,其具有巨大的潜力来彻底改变神经和精神保健,并为创新的非侵入式脑传感技术的持续进步奠定基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd15/11274405/1e0a199ec884/biosensors-14-00335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd15/11274405/bfc9a7b5badb/biosensors-14-00335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd15/11274405/1e0a199ec884/biosensors-14-00335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd15/11274405/bfc9a7b5badb/biosensors-14-00335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd15/11274405/1e0a199ec884/biosensors-14-00335-g002.jpg

相似文献

[1]
Non-Invasive Brain Sensing Technologies for Modulation of Neurological Disorders.

Biosensors (Basel). 2024-7-9

[2]
Effects of cerebellar neuromodulation in movement disorders: A systematic review.

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[3]
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[4]
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[5]
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Clin Neurophysiol. 2024-8

[6]
Neuromodulation techniques - From non-invasive brain stimulation to deep brain stimulation.

Neurotherapeutics. 2024-4

[7]
Brain stimulation: a therapeutic approach for the treatment of neurological disorders.

CNS Neurosci Ther. 2022-1

[8]
Neuromodulation of cognition in Parkinson's disease.

Prog Brain Res. 2022

[9]
Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment.

J Neurol Sci. 2020-11-15

[10]
Non-invasive brain stimulation for Parkinson's disease: Current concepts and outlook 2015.

NeuroRehabilitation. 2015

引用本文的文献

[1]
Effects of induced electric field on the sensitivity of a two-compartment neuron model.

PLoS One. 2025-5-20

[2]
Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain.

Front Neurosci. 2025-4-30

[3]
Advances in magnetic field approaches for non-invasive targeting neuromodulation.

Front Hum Neurosci. 2025-4-28

[4]
Brain Stimulation Techniques in Research and Clinical Practice: A Comprehensive Review of Applications and Therapeutic Potential in Parkinson's Disease.

Brain Sci. 2024-12-27

本文引用的文献

[1]
Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer's disease and aging mice.

Fundam Res. 2022-3-9

[2]
New results on bifurcation for fractional-order octonion-valued neural networks involving delays.

Network. 2024-4-5

[3]
Modulatory Effect of Low-Intensity Transcranial Ultrasound Stimulation on Behaviour and Neural Oscillation in Mouse Models of Alzheimer's Disease.

IEEE Trans Neural Syst Rehabil Eng. 2024

[4]
Evaluation of Patient's Quality of Life before and after Implantation of Abbott's Proclaim™ XR Spinal Cord Stimulator with BurstDR™ Stimulation in Chronic Pain Syndrome.

Medicina (Kaunas). 2023-12-17

[5]
Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders.

Bioelectron Med. 2023-11-22

[6]
Optogenetic Neuromodulation in Inflammatory Pain.

Neuroscience. 2024-1-9

[7]
Miniature battery-free bioelectronics.

Science. 2023-11-10

[8]
Durable effects of deep brain ultrasonic neuromodulation on major depression: a case report.

J Med Case Rep. 2023-10-28

[9]
Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges.

APL Bioeng. 2023-9-27

[10]
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments.

Transl Psychiatry. 2023-8-14

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