Suntinger Katharina, Dalbert Adrian, Prochazka Lukas, Tegelkamp Milena, Kronen Peter, Klein Karina, Röösli Christof, Huber Alexander, Pfiffner Flurin
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.
Musculoskeletal Research Unit, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Brain Sci. 2025 Jan 14;15(1):69. doi: 10.3390/brainsci15010069.
The brainstem auditory-evoked response (BAER) is an established electrophysiological measure of neural activity from the auditory nerve up to the brain stem. The BAER is used to diagnose abnormalities in auditory pathways and in neurophysiological human and animal research. However, normative data for BAERs in sheep, which represent an adequate large animal model for translational and basic otological research, are lacking. The aim of this study was to assess the function of the ovine auditory nervous system by determining normative values for the BAER and to compare sheep with human BAER data. In this retrospective study, BAER data for click stimuli at a range of sound pressure levels (SPLs) were analyzed. A series of 15 samples from six sheep with a mean age of 41.8 months was included. The mean BAER threshold was 45.3 dB SPL. At 100 dB SPL, the mean (±standard deviation, SD) latency of wave V was 4.35 (±0.18) ms, that of wave III was 2.44 (±0.15) ms, and that of wave I was 0.88 (±0.13) ms. At 100 dB SPL, the mean interpeak latency of waves I-III was 1.56 (±0.18) ms, that of waves III-V was 1.91 (±0.16) ms, and that of waves I-V was 3.47 (±0.20) ms. The mean amplitudes at 100 dB SPL were 0.04 (±0.03) µV for wave I, 0.50 (±0.24) µV for wave III, and 0.40 (±0.25) µV for wave V. The normative values for sheep BAERs were reproducible and similar to those of humans. The normative BAER values further support sheep as an adequate animal model for otological research.
脑干听觉诱发电位（BAER）是一种已确立的用于测量从听神经到脑干神经活动的电生理指标。BAER用于诊断听觉通路异常以及在人类和动物神经生理学研究中。然而，绵羊的BAER规范数据却很缺乏，而绵羊是用于转化和基础耳科学研究的合适的大型动物模型。本研究的目的是通过确定BAER的规范值来评估绵羊听觉神经系统的功能，并将绵羊与人类的BAER数据进行比较。在这项回顾性研究中，分析了一系列不同声压级（SPL）下短声刺激的BAER数据。纳入了来自6只绵羊的15个样本系列，平均年龄为41.8个月。BAER平均阈值为45.3 dB SPL。在100 dB SPL时，V波的平均（±标准差，SD）潜伏期为4.35（±0.18）ms，III波为2.44（±0.15）ms，I波为0.88（±0.13）ms。在100 dB SPL时，I-III波的平均峰间潜伏期为1.56（±0.18）ms，III-V波为1.91（±0.16）ms，I-V波为3.47（±0.20）ms。在100 dB SPL时，I波的平均波幅为0.04（±0.03）µV，III波为0.50（±0.24）µV，V波为0.40（±0.25）µV。绵羊BAER的规范值具有可重复性且与人类的相似。BAER规范值进一步支持绵羊作为耳科学研究的合适动物模型。
