Paolini Federica, Marrone Salvatore, Scalia Gianluca, Gerardi Rosa Maria, Bonosi Lapo, Benigno Umberto Emanuele, Musso Sofia, Scerrati Alba, Iacopino Domenico Gerardo, Signorelli Francesco, Maugeri Rosario, Visocchi Massimiliano
Neurosurgical Clinic, AOUP "Paolo Giaccone", Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Unit of Neurosurgery, Sant'Elia Hospital, 93100 Caltanissetta, Italy.
Brain Sci. 2025 Jan 14;15(1):70. doi: 10.3390/brainsci15010070.
: Diffusion tensor imaging (DTI), a variant of Diffusion Weighted Imaging (DWI), enables a neuroanatomical microscopic-like examination of the brain, which can detect brain damage using physical parameters. DTI's application to traumatic brain injury (TBI) has the potential to reveal radiological features that can assist in predicting the clinical outcomes of these patients. What is the ongoing role of DTI in detecting brain alterations and predicting neurological outcomes in patients with moderate to severe traumatic brain injury and/or diffuse axonal injury? : A scoping review of the PubMed, Scopus, EMBASE, and Cochrane databases was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The aim was to identify all potentially relevant studies concerning the role of DTI in TBI. From an initial pool of 3527 publications, 26 articles were selected based on relevance. These studies included a total of 729 patients with moderate to severe TBI and/or diffuse axonal injury. DTI parameters were analyzed to determine their relationship with neurological outcomes post-TBI, with assessments of several brain functions and regions. : The studies included various DTI parameters, identifying significant relationships between DTI variations and neurological outcomes following TBI. Multiple brain functions and regions were evaluated, demonstrating the capability of DTI to detect brain alterations with higher accuracy, sensitivity, and specificity than MRI alone. : DTI is a valuable tool for detecting brain alterations in TBI patients, offering enhanced accuracy, sensitivity, and specificity compared to MRI alone. Recent studies confirm its effectiveness in identifying neurological impairments and predicting outcomes in patients following brain trauma, underscoring its utility in clinical settings for managing TBI.
扩散张量成像（DTI）是扩散加权成像（DWI）的一种变体，能够对大脑进行类似神经解剖学显微镜检查，可利用物理参数检测脑损伤。DTI应用于创伤性脑损伤（TBI）有可能揭示有助于预测这些患者临床结局的放射学特征。DTI在检测中度至重度创伤性脑损伤和/或弥漫性轴索损伤患者的脑改变及预测神经学结局方面目前发挥着什么作用？：根据系统评价和Meta分析的首选报告项目（PRISMA）指南，对PubMed、Scopus、EMBASE和Cochrane数据库进行了范围综述。目的是确定所有与DTI在TBI中的作用潜在相关的研究。从最初的3527篇出版物中，根据相关性选择了26篇文章。这些研究共纳入729例中度至重度TBI和/或弥漫性轴索损伤患者。分析DTI参数以确定其与TBI后神经学结局的关系，并对多种脑功能和脑区进行评估。：这些研究纳入了各种DTI参数，确定了DTI变化与TBI后神经学结局之间的显著关系。对多种脑功能和脑区进行了评估，表明DTI比单独的MRI更能以更高的准确性、敏感性和特异性检测脑改变。：DTI是检测TBI患者脑改变的一种有价值的工具，与单独的MRI相比，具有更高的准确性、敏感性和特异性。最近的研究证实了其在识别脑外伤患者的神经功能障碍和预测结局方面的有效性，强调了其在TBI临床管理中的实用性。
