Estudillo Enrique, Castillo-Arellano Jorge Iván, Martínez Emilio, Rangel-López Edgar, López-Ornelas Adolfo, Magaña-Maldonado Roxana, Adalid-Peralta Laura, Velasco Iván, Escobedo-Ávila Itzel
Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Cells. 2025 Jan 7;14(2):70. doi: 10.3390/cells14020070.
Our knowledge about the consumption of cannabinoids during pregnancy lacks consistent evidence to determine whether it compromises neurodevelopment. Addressing this task is challenging and complex since pregnant women display multiple confounding factors that make it difficult to identify the real effect of cannabinoids' consumption. Recent studies shed light on this issue by using pluripotent stem cells of human origin, which can recapitulate human neurodevelopment. These revolutionary platforms allow studying how exogenous cannabinoids could alter human neurodevelopment without ethical concerns and confounding factors. Here, we review the information to date on the clinical studies about the impact of exogenous cannabinoid consumption on human brain development and how exogenous cannabinoids alter nervous system development in humans using cultured pluripotent stem cells as 2D and 3D platforms to recapitulate brain development.
我们对于孕期大麻素摄入情况的了解，缺乏确定其是否会损害神经发育的一致证据。解决这一任务具有挑战性且十分复杂，因为孕妇存在多种混杂因素，这使得难以确定大麻素摄入的实际影响。最近的研究通过使用人类多能干细胞来阐明这一问题，这些干细胞可以重现人类神经发育过程。这些革命性的平台能够在没有伦理问题和混杂因素的情况下，研究外源性大麻素如何改变人类神经发育。在此，我们回顾了迄今为止有关外源性大麻素摄入对人类大脑发育影响的临床研究信息，以及外源性大麻素如何利用培养的多能干细胞作为二维和三维平台来重现大脑发育，从而改变人类神经系统发育的相关信息。
