Boiangiu Andreea, Cioca Ana-Maria, Gorecki Gabriel-Petre, Sima Romina-Marina, Pleș Liana, Novac Marius-Bogdan, Coman Ionut-Simion, Grigorean Valentin-Titus, Lungu Vasile, Georgescu Mihai-Teodor, Filipescu George-Alexandru
Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Obstetrics and Gynecology, Elias University Hospital, 011461 Bucharest, Romania.
Curr Oncol. 2024 Dec 25;32(1):4. doi: 10.3390/curroncol32010004.
Vulvar cancer is one of the rarest gynecological malignancies. The development of this condition can be associated with either dysplasia linked to human papillomavirus (HPV), primarily affecting younger women, or vulvar dermatoses such as lichen sclerosus, which predominantly affect older women. Over the last decade, the incidence of vulvar cancer has risen by 0.6% annually, while the relative survival rate has declined. Although metastasis to the vulva is uncommon, it can occur, particularly from cancers in nearby organs such as the cervix, bladder, rectum, or anus. More rarely, metastases from breast cancer and renal cell carcinoma have been reported in the vulva. Vaginal metastases from clear cell renal carcinoma are especially rare. In this article, we present the case of a 56-year-old patient diagnosed with clear cell renal carcinoma, who came to our clinic with a lesion on the right labia, which was identified as a metastasis originating from the kidney. Given the rarity of genital metastases in renal cancer, such cases should be examined and discussed to encourage further research and studies.
外阴癌是最罕见的妇科恶性肿瘤之一。这种疾病的发生可能与人类乳头瘤病毒（HPV）相关的发育异常有关，主要影响年轻女性，或者与外阴皮肤病如硬化性苔藓有关，后者主要影响老年女性。在过去十年中，外阴癌的发病率每年上升0.6%，而相对生存率却有所下降。虽然转移至外阴并不常见，但仍有可能发生，特别是来自附近器官如子宫颈、膀胱、直肠或肛门的癌症转移。更罕见的是，有报道称乳腺癌和肾细胞癌可转移至外阴。透明细胞肾细胞癌的阴道转移尤其罕见。在本文中，我们报告了一例56岁被诊断为透明细胞肾细胞癌的患者，该患者因右侧阴唇出现病变前来我院就诊，该病变被确定为源自肾脏的转移瘤。鉴于肾癌发生生殖器转移非常罕见，应对此类病例进行检查和讨论，以鼓励进一步的研究。
