Salagean Alex-Adrian, Moldovan Cezara-Anca-Denisa, Slevin Mark
Department of Histology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.
School of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, Romania.
Gels. 2025 Jan 8;11(1):50. doi: 10.3390/gels11010050.
HA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA-originally identified as a mechanism for maintaining longevity in the naked mole-rat-as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease.
近年来，透明质酸（HA）被认为是一种天然存在的可修饰的凝胶状支架，它能够在较长时间内吸收和释放药物，使其适合作为一种潜在的化疗药物递送剂。考虑到胶质母细胞瘤治疗中可用的治疗选择有限，在本综述中，我们讨论了超高分子量HA的新用途——最初被确定为裸鼹鼠维持长寿的一种机制——作为一种保护性和优化细胞外基质的胶体支架，以及一种在切除的脑肿瘤中递送治疗的手段。这种独特形式的HA交联凝胶的独特性质表明其在预防和治疗基于增殖和炎症驱动的疾病方面具有潜在的未来用途。
