Xue Gang, Zhang Ruiping, Chen Yihao, Xu Wei, Zhang Changxing
Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650500, China.
Intelligent Infrastructure Operation and Maintenance Technology Innovation Team of Yunnan Provincial Department of Education, Kunming University of Science and Technology, Kunming 650500, China.
Biosensors (Basel). 2025 Jan 4;15(1):17. doi: 10.3390/bios15010017.
Continuous glucose monitoring based on the minimally invasive implantation of glucose sensor is characterized by high accuracy and good stability. At present, glucose concentration monitoring based on fluorescent glucose capsule sensor is a new development trend. In this paper, we design a fluorescent glucose capsule sensor with a design optimization study. The motion trajectory of incident light in the fluorescent gel layer is simulated based on the Monte Carlo method, and the cloud maps of light intensity with the light intensity distribution at the light-receiving layer are plotted. Altering the density of fluorescent molecules, varying the thickness of tissue layers, and adjusting the angle of incidence deflection, the study investigates the influence of these parameter changes on the optimal position of reflected light at the bottom. Finally, the simulation results were utilized to design and fabricate a fluorescent glucose capsule sensor. Rabbit subcutaneous tissue glucose level tests and real-time glucose solution concentration monitoring experiments were performed. This work contributes to the real-time monitoring of glucose levels and opens up new avenues for research on fabricating glucose sensors.
基于葡萄糖传感器微创植入的连续血糖监测具有高精度和良好稳定性的特点。目前，基于荧光葡萄糖胶囊传感器的葡萄糖浓度监测是一个新的发展趋势。在本文中，我们设计了一种荧光葡萄糖胶囊传感器并进行了设计优化研究。基于蒙特卡罗方法模拟了入射光在荧光凝胶层中的运动轨迹，并绘制了光接收层处光强与光强分布的云图。通过改变荧光分子密度、改变组织层厚度以及调整入射角偏转，研究了这些参数变化对底部反射光最佳位置的影响。最后，利用模拟结果设计并制作了一种荧光葡萄糖胶囊传感器。进行了兔皮下组织葡萄糖水平测试和实时葡萄糖溶液浓度监测实验。这项工作有助于葡萄糖水平的实时监测，并为葡萄糖传感器的制造研究开辟了新途径。
