深静脉血栓形成的发生与骨折部位有关吗？一项两样本孟德尔随机化研究。

Is the occurrence of deep vein thrombosis related to the fracture site? A two-sample Mendelian randomization study.

作者信息

Yang Mingyi, Su Yani, Wen Pengfei, Xie Jiale, Wan Xianjie, Xu Ke, Jing Wensen, Yang Zhi, Liu Lin, Xu Peng

机构信息

Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

出版信息

Expert Rev Hematol. 2025 Feb;18(2):155-165. doi: 10.1080/17474086.2025.2459251. Epub 2025 Jan 27.

DOI:10.1080/17474086.2025.2459251

PMID:39852237

Abstract

OBJECTIVE

Deep vein thrombosis (DVT) is a known complication of fractures. This study aimed to explore the genetic causal relationship between DVT and fracture sites.

RESEARCH DESIGN AND METHODS

The exposures analyzed in this study included fracture of femur (FFE), fracture of lower leg, including ankle (FLLA), fracture of shoulder and upper arm (FSUA), fracture of forearm (FFO), fracture of rib, sternum and thoracic spine (FRSTS) and fracture of lumbar spine and pelvis (FLSP). DVT as the outcome. A two-sample Mendelian randomization (MR) approach was employed to investigate the genetic causal relationship, and a series of sensitivity analyses were conducted.

RESULTS

The findings indicated no genetic causal relationship between FFE ( = 0.569, OR 95% CI = 1.001 [0.998-1.003]), FLLA ( = 0.371, OR 95% CI = 0.999 [0.995-1.002]), FSUA ( = 0.871, OR 95% CI = 1.000 [0.998-1.002]), FFO ( = 0.281, OR 95% CI = 1.001 [0.999-1.002]), FRSTS ( = 0.346, OR 95% CI = 0.999 [0.996-1.001]) or FLSP ( = 0.759, OR 95% CI = 1.000 [0.999-1.002]) and DVT. Sensitivity analyses reinforced the robustness.

CONCLUSIONS

This study indicate that no genetic causal relationship exists between DVT and fracture site, the observed association may be attributable to non-genetic factors.

摘要

目的

深静脉血栓形成（DVT）是骨折已知的并发症。本研究旨在探讨DVT与骨折部位之间的遗传因果关系。

研究设计与方法

本研究分析的暴露因素包括股骨骨折（FFE）、小腿骨折（包括踝关节骨折，FLLA）、肩部和上臂骨折（FSUA）、前臂骨折（FFO）、肋骨、胸骨和胸椎骨折（FRSTS）以及腰椎和骨盆骨折（FLSP）。以DVT作为结局。采用两样本孟德尔随机化（MR）方法研究遗传因果关系，并进行了一系列敏感性分析。

结果

研究结果表明，FFE（=0.569，OR 95%CI=1.001[0.998-1.003]）、FLLA（=0.371，OR 95%CI=0.999[0.995-1.002]）、FSUA（=0.871，OR 95%CI=1.000[0.998-1.002]）、FFO（=0.281，OR 95%CI=1.001[0.999-1.002]）、FRSTS（=0.346，OR 95%CI=0.999[0.996-1.001]）或FLSP（=0.759，OR 95%CI=1.000[0.999-1.002]）与DVT之间不存在遗传因果关系。敏感性分析增强了结果的稳健性。