Lopes José Lucas Xavier, Raimondo Raquel Fraga E Silva, Jacondino Luiza Rodegheri, Correa Beatriz Riet, Mori Clara Satsuki, Pöppl Álan Gomes
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91540-000, Brazil.
Núcleo RuminAção, Ensino, Pesquisa e Extensão em Ruminantes, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91540-000, Brazil.
Vet Sci. 2025 Jan 11;12(1):47. doi: 10.3390/vetsci12010047.
Pregnant ewes are susceptible to hypoglycemia and ketosis; therefore, monitoring glycemic status is extremely important. Portable blood glucose meters (PBGMs) can assist in quickly and conveniently identifying glycemic disturbances in this species, provided that they meet the criteria of analytical accuracy. This study evaluated the performance of a human PBGM (Accu-Chek Performa, Roche Diagnostics, Basel, Switzerland) in the glycemic evaluation of 34 pregnant ewes at days 90 and 120 of pregnancy in comparison with the results of glycemia determination by a reference method (RM). The device showed a high positive correlation (r = 0.71, 95%CI = 0.57-0.82, < 0.0001) with the RM; however, 96.6% of the PBGM results (58.5 ± 9.82 mg/dL) were higher ( < 0.0001) than those obtained in the laboratory (48.6 ± 9.31 mg/dL). The PBGM tested was considered analytically inaccurate according to ISO 15197:2013, which states that when glucose levels are below 100 mg/dL, 95% of the measurements should deviate by no more than 15 mg/dL from the RM value, and 1/3 of the PBGM results were above this limit. Hypoglycemia (<50 mg/dL) was documented in 60.29% of samples tested on with the RM, but only 17.64% of results were below 50 mg/dL using the PBGM. Due to these limitations, Accu-Check Performa results should be interpreted cautiously in pregnant sheep suspected of hypoglycemia.
怀孕母羊易患低血糖和酮症；因此，监测血糖状态极为重要。便携式血糖仪（PBGMs）只要符合分析准确性标准，就能协助快速便捷地识别该物种的血糖紊乱情况。本研究评估了一款人用便携式血糖仪（Accu-Chek Performa，罗氏诊断公司，瑞士巴塞尔）在34只怀孕母羊妊娠第90天和120天时血糖评估中的性能，并与参考方法（RM）测定的血糖结果进行比较。该设备与参考方法显示出高度正相关（r = 0.71，95%CI = 0.57 - 0.82，< 0.0001）；然而，便携式血糖仪结果的96.6%（58.5 ± 9.82 mg/dL）高于实验室获得的结果（48.6 ± 9.31 mg/dL）（< 0.0001）。根据ISO 15197:2013，所测试的便携式血糖仪在分析上被认为不准确，该标准规定，当血糖水平低于100 mg/dL时，95%的测量值与参考方法值的偏差不应超过15 mg/dL，而便携式血糖仪结果的三分之一高于此限值。参考方法检测的样本中有60.29%记录到低血糖（<50 mg/dL），但使用便携式血糖仪时只有17.64%的结果低于50 mg/dL。由于这些局限性，对于怀疑有低血糖的怀孕母羊，Accu-Chek Performa的结果应谨慎解读。
