Pașca Paula Maria, Solcan Gheorghe, Blageanu Andrei, Lăcătuș Caroline Maria, Peștean Petru Cosmin, Stancu Constantin Adrian, Baisan Andrei Radu
Department of Clinics, Faculty of Veterinary Medicine, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 700490 Iasi, Romania.
Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Vet Sci. 2025 Jan 16;12(1):63. doi: 10.3390/vetsci12010063.
A 3-year-old spayed male mixed-breed Labrador presented to the Emergency and Critical Care Unit with lethargy, loss of appetite, vomiting, a recent history of presyncopal episodes, and severe exercise intolerance. On admission, the patient had bradycardia, low blood pressure, and mild abdominal pain. Serum biochemistry information revealed severe hyperkalemia, hyponatremia, hypoglycemia, and mildly increased liver and kidney parameters. Upon taking these findings into consideration, hypoadrenocorticism was suspected, and a basal cortisol level was determined; it was below 1.0 µg/dL. Upon examination with ultrasound, we observed that the size of the adrenal glands was considerably reduced. Due to the bradycardia, a complete cardiologic examination consisting of 5 min of six-lead electrocardiography and echocardiography (ECG) was performed. Six-lead ECG revealed a complete atrio-ventricular block with an atrial rate of 140 bpm and a ventricular rate of 60 bpm. The PQ interval was variable, without any evidence of atrio-ventricular conduction. Treatment for hyperkalemia was initiated immediately after admission, followed by dexamethasone sodium phosphate administration, which led to an improvement in the patient's general condition, and the normalization of the ECG readings, after 24 h of therapy. Afterward, prednisolone (0.5 mg/kg/24 h p.o.) and desoxycorticosterone pivalate (2.2 mg/kg s.c.) were administered. This case shows that a third-degree atrioventricular block might be a reversible problem in dogs with hypoadrecorticism that can be managed with specific treatment for this disorder, without requiring pacemaker implantation.
一只3岁已绝育的雄性混种拉布拉多犬被送至急诊与重症监护病房,出现嗜睡、食欲不振、呕吐、近期有晕厥前期发作史以及严重运动不耐受症状。入院时,该患者心动过缓、血压低且有轻度腹痛。血清生化检查结果显示严重高钾血症、低钠血症、低血糖以及肝肾功能参数轻度升高。综合这些检查结果,怀疑为肾上腺皮质功能减退症,并测定了基础皮质醇水平,结果低于1.0µg/dL。超声检查发现肾上腺体积明显缩小。由于心动过缓,进行了包括5分钟六导联心电图和超声心动图(ECG)的完整心脏检查。六导联心电图显示完全性房室传导阻滞,心房率为140次/分钟,心室率为60次/分钟。PQ间期可变,无房室传导证据。入院后立即开始治疗高钾血症,随后给予地塞米松磷酸钠,治疗24小时后患者一般状况改善,心电图读数恢复正常。之后,给予泼尼松龙(0.5mg/kg/24小时口服)和醋氧皮质酮(2.2mg/kg皮下注射)。该病例表明,三度房室传导阻滞在患有肾上腺皮质功能减退症的犬中可能是一个可逆问题,可通过针对该疾病的特定治疗进行处理,无需植入起搏器。