Organophosphorus Pesticides Management Strategies: Prohibition and Restriction Multi-Category Multi-Class Models, Environmental Transformation Risks, and Special Attention List.

Organophosphorus pesticides (OPs) have become one of the most widely used pesticides in Chinese agriculture; however, methods to identify potential restrictions on OPs molecules are lacking. Therefore, this study retrieved the OPs restriction list and constructed eight multi-class, multi-category machine learning models for OPs restrictions. Among these, the random forest (RF) model demonstrated excellent predictive performance, as it was successfully validated and applied. Potential environmental transformation products of OPs were obtained using EAWAG-BBD software, while toxicity indicators for the parent OPs and their transformation products were predicted with ADMETlab 3.0 software. This study found that unrestricted OPs, such as phorate, parathion, and chlorpyrifos, exhibited a high probability of toxicity. Additionally, the environmental transformation products of OPs posed similar comprehensive toxicity risks as the parent compounds. A special attention list for OPs was created based on the toxicity risks of unrestricted parent OPs and their transformation products, using standard deviation classification. Phorate and parathion were identified as OPs requiring special attention. This paper aims to provide an effective method for identifying the potential restriction levels of OPs and to propose an evaluation system that comprehensively considers the health risk, thereby supporting the improvement and optimization of management and usage strategies for OPs.