Qian Ziyi, Dai Chenxu, Chen Siyan, Yang Linjie, Huo Xia
Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, College of Environment and Climate, Jinan University, Guangzhou 511443, China.
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China.
Toxics. 2025 Jan 9;13(1):46. doi: 10.3390/toxics13010046.
Volatile organic compounds (VOCs) are associated with obesity health risks, while the association of mixed VOCs with visceral adiposity indicators remains unclear. In this study, a total of 2015 adults from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted generalized linear models, restricted cubic spline (RCS), weighted quantile sum (WQS), and Bayesian kernel machine regression (BKMR) were adopted to assess the association of VOC metabolites (mVOCs) with the visceral adiposity index (VAI) and lipid accumulation product (LAP). Multiple mVOCs were positively associated with the VAI and LAP in the single-exposure model, especially N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA) and N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC). The associations of mVOCs with VAI and LAP were more significant in <60-year-old and non-obese individuals, with interactions of CEMA with age and AMCC with obesity status. Nonlinear relationships between certain mVOCs and the VAI or the LAP were also observed. In the WQS model, co-exposure to mVOCs was positively correlated with the VAI [β (95%CI): 0.084 (0.022, 0.147)]; CEMA (25.24%) was the major contributor. The result of the BKMR revealed a positive trend of the association between mixed mVOCs and the VAI. Our findings suggest that VOC exposure is strongly associated with visceral obesity indicators. Further large prospective investigations are necessary to support our findings.
挥发性有机化合物（VOCs）与肥胖健康风险相关，而混合VOCs与内脏脂肪指标之间的关联仍不明确。在本研究中，纳入了来自美国国家健康与营养检查调查（NHANES）的2015名成年人。采用加权广义线性模型、受限立方样条（RCS）、加权分位数和（WQS）以及贝叶斯核机器回归（BKMR）来评估VOC代谢物（mVOCs）与内脏脂肪指数（VAI）和脂质蓄积产物（LAP）之间的关联。在单暴露模型中，多种mVOCs与VAI和LAP呈正相关，尤其是N-乙酰-S-（2-羧乙基）-L-半胱氨酸（CEMA）和N-乙酰-S-（N-甲基氨基甲酰）-L-半胱氨酸（AMCC）。mVOCs与VAI和LAP的关联在<60岁和非肥胖个体中更为显著，CEMA与年龄以及AMCC与肥胖状态之间存在相互作用。还观察到某些mVOCs与VAI或LAP之间存在非线性关系。在WQS模型中，mVOCs的共同暴露与VAI呈正相关[β（95%CI）：0.084（0.022，0.147）]；CEMA（25.24%）是主要贡献者。BKMR的结果显示混合mVOCs与VAI之间的关联呈正趋势。我们的研究结果表明，VOC暴露与内脏肥胖指标密切相关。需要进一步进行大规模前瞻性研究来支持我们的发现。
