Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lipids Health Dis. 2024 Apr 10;23(1):100. doi: 10.1186/s12944-024-02081-5.
Obesity refers to a significant contributor to the development of obstructive sleep apnea (OSA). Early prediction of OSA usually leads to better treatment outcomes, and this study aims to employ novel metabolic markers, visceral adiposity index (VAI), and lipid accumulation product (LAP) to evaluate the relationship to OSA.
The data used in the current cross-sectional investigation are from the National Health and Nutrition Examination Survey (NHANES), which was carried out between 2015 and 2018. To examine the correlation between LAP and VAI levels and OSA, multivariate logistic regression analysis was adopted. In addition, various analytical methods were applied, including subgroup analysis, smooth curve fitting, and threshold effect analysis.
Among totally 3932 participants, 1934 were included in the OSA group. The median (Q1-Q3) values of LAP and VAI for the participants were 40.25 (21.51-68.26) and 1.27 (0.75-2.21), respectively. Logistic regression studies indicated a positive correlation between LAP, VAI, and OSA risk after adjusting for potential confounding variables. Subgroup analysis revealed a stronger correlation between LAP, VAI levels, and OSA among individuals aged < 60 years. Through smooth curve fitting, specific saturation effects of LAP, VAI, and BMD were identified, with inflection points at 65.684 and 0.428, respectively.
This study demonstrates that elevated levels of LAP and VAI increase the risk of OSA, suggesting their potential as predictive markers for OSA and advocating for dietary and exercise interventions to mitigate OSA risk in individuals with high LAP and VAI levels.
肥胖是导致阻塞性睡眠呼吸暂停（OSA）的重要因素。OSA 的早期预测通常会带来更好的治疗效果，本研究旨在利用新的代谢标志物——内脏脂肪指数（VAI）和脂积指数（LAP）来评估其与 OSA 的关系。
本横断面研究的数据来自于国家健康和营养检查调查（NHANES），该调查于 2015 年至 2018 年进行。为了检验 LAP 和 VAI 水平与 OSA 的相关性，采用了多变量逻辑回归分析。此外，还应用了各种分析方法，包括亚组分析、平滑曲线拟合和阈值效应分析。
在总共 3932 名参与者中，有 1934 名被纳入 OSA 组。参与者的 LAP 和 VAI 的中位数（Q1-Q3）值分别为 40.25（21.51-68.26）和 1.27（0.75-2.21）。经潜在混杂因素调整后，logistic 回归研究表明 LAP、VAI 与 OSA 风险呈正相关。亚组分析显示，在年龄<60 岁的个体中，LAP、VAI 水平与 OSA 之间的相关性更强。通过平滑曲线拟合，发现 LAP、VAI 和 BMD 存在特定的饱和效应，拐点分别为 65.684 和 0.428。
本研究表明，LAP 和 VAI 水平升高会增加 OSA 的风险，提示它们可能成为 OSA 的预测标志物，并提倡通过饮食和运动干预来降低高 LAP 和 VAI 水平个体的 OSA 风险。
