Department of Emergency, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518003, PR China.
Department of Emergency, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510120, PR China.
Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167113. doi: 10.1016/j.bbadis.2024.167113. Epub 2024 Mar 7.
Hypertension, a prevalent cardiovascular ailment globally, can precipitate numerous complications, notably hypertensive cardiomyopathy. Meteorin-like (METRNL) is demonstrated to possess potential protective properties on cardiovascular diseases. However, its specific role and underlying mechanism in hypertensive myocardial hypertrophy remain elusive. Spontaneously hypertensive rats (SHRs) served as hypertensive models to explore the effects of METRNL on hypertension and its induced myocardial hypertrophy. The research results indicate that, in contrast to Wistar-Kyoto (WKY) rats, SHRs exhibit significant symptoms of hypertension and myocardial hypertrophy, but cardiac-specific overexpression (OE) of METRNL can partially ameliorate these symptoms. In H9c2 cardiomyocytes, METRNL suppresses Ang II-induced autophagy by controlling the BRCA2/Akt/mTOR signaling pathway. But when BRCA2 expression is knocked down, this effect will be suppressed. Collectively, METRNL emerges as a potential therapeutic target for hypertensive cardiomyopathy.
高血压是一种全球范围内普遍存在的心血管疾病，可引发多种并发症，尤其是高血压性心肌病。 Meteorin-like（METRNL）被证明对心血管疾病具有潜在的保护作用。然而，其在高血压心肌肥厚中的具体作用和潜在机制仍不清楚。自发性高血压大鼠（SHRs）被用作高血压模型，以探究 METRNL 对高血压及其诱导的心肌肥厚的影响。研究结果表明，与 Wistar-Kyoto（WKY）大鼠相比，SHRs 表现出明显的高血压和心肌肥厚症状，但心脏特异性过表达（OE）METRNL 可部分改善这些症状。在 H9c2 心肌细胞中，METRNL 通过控制 BRCA2/Akt/mTOR 信号通路抑制 Ang II 诱导的自噬。但是当 BRCA2 表达被敲低时，这种作用将会被抑制。总之，METRNL 可能成为高血压性心肌病的一种潜在治疗靶点。
