Karim A C
Anat Rec. 1985 Jan;211(1):17-23. doi: 10.1002/ar.1092110104.
The effect of adriamycin on rat incisor was investigated 1 day after administration. Rats were injected intravenously with adriamycin at a dose of 5 mg/kg body weight and sacrificed by perfusion with a 2.5% phosphate buffered glutaraldehyde solution. The principal effect of the drug on the incisor was the production of cell degeneration. This was extensive in the apical region, being present along the entire periphery of the dental papilla. In sections examined more incisally, cell degeneration gradually disappeared from the labial portion of the incisor but was present in the lingual portion. This degeneration of cells was not present at the site where mature odontoblasts had differentiated on the lingual surface of the pulp chamber. It appears that the affected cells were early preodontoblasts and the precursors of preodontoblasts. However, as these cells became more differentiated they apparently became more resistant to the drug's effect.
给药1天后，研究了阿霉素对大鼠切牙的影响。给大鼠静脉注射剂量为5mg/kg体重的阿霉素，然后用2.5%的磷酸盐缓冲戊二醛溶液灌注处死。该药物对切牙的主要作用是导致细胞变性。这种变性在根尖区域广泛存在，沿牙乳头的整个周边都有。在更靠近切端检查的切片中，细胞变性从切牙的唇侧部分逐渐消失，但在舌侧部分仍然存在。在牙髓腔舌侧表面已分化出成熟成牙本质细胞的部位不存在这种细胞变性。看来受影响的细胞是早期前成牙本质细胞和成牙本质细胞前体。然而，随着这些细胞分化程度更高，它们显然对药物的作用更具抗性。
