Dahl J E
Scand J Dent Res. 1984 Feb;92(1):6-13. doi: 10.1111/j.1600-0722.1984.tb00853.x.
Three groups of female Wistar rats were intravenously injected with the antineoplastic drug doxorubicin in a single dose of 5 mg/kg, 10 mg/kg and 20 mg/kg, respectively. The animals were killed 1 and 5 days after injection. Paraffin and Vestopal W embedded sections were prepared of the maxillary right and left incisors, respectively, and evaluated by light microscopy. Doxorubicin produced necrosis of single cells, of small groups of cells in the basal pulp and destroyed the preodontoblasts as evaluated 1 day after injection. On the 5th day of observation, the late preodontoblasts and basal pulp had regenerated, but the early preodontoblast zone remained absent, leading to an abnormal odontogenesis. This caused a marked reduction of dentin deposition in the apical part of the tooth and production of irregular predentin by cells in the pulp and by the young odontoblasts.
将三组雌性Wistar大鼠分别静脉注射剂量为5毫克/千克、10毫克/千克和20毫克/千克的抗肿瘤药物阿霉素。注射后1天和5天处死动物。分别制备右上颌和左上颌切牙的石蜡包埋切片和Vestopal W包埋切片，并通过光学显微镜进行评估。注射后1天评估发现，阿霉素导致单个细胞、牙髓基部小细胞群坏死，并破坏前成牙本质细胞。在观察的第5天，晚期前成牙本质细胞和牙髓基部已经再生，但早期前成牙本质细胞区仍然缺失，导致牙发育异常。这导致牙齿根尖部牙本质沉积明显减少，牙髓细胞和年轻成牙本质细胞产生不规则的前期牙本质。
