Karim A C, Pylypas S P
Exp Pathol. 1985;27(2):105-10. doi: 10.1016/s0232-1513(85)80047-5.
The extent of the necrotic lesion produced by adriamycin in the apical end of the rat incisor was investigated. Male Sprague Dawley rats were injected intravenously with adriamycin (5 mg/kg body weight), and sacrificed by perfusion with a 2.5% buffered glutaraldehyde solution 1 d after injection. Controls injected with only physiological saline were treated in the same manner. One micron thick plastic serial sections were prepared from the apical end of the incisor, and a schematic representation of the entire lesion as seen in longitudinal section was reproduced from each fiftieth section. Cell destruction was observed for 2.2 mm within the pulp. The lesion extended further incisally in the lingual portion than in the labial portion. The bulbous portion of the odontogenic organ was not affected. This study indicates that the cytotoxicity of adriamycin appears to affect mainly proliferating immature precursor cells within the mesenchyma, and the preodontoblasts.
研究了阿霉素对大鼠切牙顶端产生的坏死病变范围。将雄性斯普拉格-道利大鼠静脉注射阿霉素（5毫克/千克体重），并在注射后1天用2.5%的缓冲戊二醛溶液灌注处死。仅注射生理盐水的对照组以相同方式处理。从切牙顶端制备1微米厚的塑料连续切片，并从每第五十张切片中复制纵切面所见整个病变的示意图。在牙髓内观察到2.2毫米范围内的细胞破坏。病变在舌侧部分比唇侧部分向切端延伸得更远。牙源性器官的球茎状部分未受影响。这项研究表明，阿霉素的细胞毒性似乎主要影响间充质内增殖的未成熟前体细胞和成牙本质细胞前体。
