Lindenskov Annika H, Potts Halla, Kristiansen Marnar F, Petersen Maria S, Strøm Marin
Centre of Health Science, University of the Faroe Islands, Tórshavn, Faroe Islands.
The Faroese Cancer Registry, Tórshavn, Faroe Islands.
Cancer Rep (Hoboken). 2025 Jan;8(1):e70066. doi: 10.1002/cnr2.70066.
Sex differences in lung cancer survival are well-established, but the gap between Faroese men and women is especially pronounced. Faroese women have some of the highest 1- and 5-year relative survival rates in the Nordic region, while Faroese men have some of the lowest. This study investigates these survival disparities by analyzing demographic, clinical, and temporal factors in Faroese lung cancer patients from 2015 to 2020.
All lung cancer cases registered in the Faroese Cancer Registry from 2015 to 2020 were included. Data on age, sex, civil status, cancer type, stage, smoking history, comorbidities, and performance status were extracted from electronic patient records. Sex-based differences were analyzed and overall survival rates were estimated using Kaplan-Meier plots.
Significant sex differences were observed in cancer staging at diagnosis (p = 0.03), with 25.8% of women diagnosed at Stage I compared to 8.8% of men. Gender-specific patterns also emerged: women hadlonger symptomatic periods, while men experienced longer diagnostic and treatment times, though with overlapping confidence intervals.
Our findings reveal significant sex disparities in lung cancer staging at diagnosis in the Faroe Islands, which may the survival differences. The longer diagnostic period in men likely contributes to their lower survival rates. These results highlight the need for targeted interventions to reduce these disparities and improve patient outcomes.
肺癌生存率的性别差异已得到充分证实，但法罗群岛男性和女性之间的差距尤为明显。法罗群岛女性的1年和5年相对生存率在北欧地区处于最高水平之列，而法罗群岛男性则处于最低水平之列。本研究通过分析2015年至2020年法罗群岛肺癌患者的人口统计学、临床和时间因素，调查这些生存差异。
纳入2015年至2020年在法罗群岛癌症登记处登记的所有肺癌病例。从电子病历中提取年龄、性别、婚姻状况、癌症类型、分期、吸烟史、合并症和体能状态等数据。分析基于性别的差异，并使用Kaplan-Meier曲线估计总体生存率。
在诊断时的癌症分期中观察到显著的性别差异（p = 0.03），25.8%的女性在I期诊断，而男性为8.8%。还出现了特定性别的模式：女性有更长的症状期，而男性的诊断和治疗时间更长，尽管置信区间有重叠。
我们的研究结果揭示了法罗群岛肺癌诊断分期中的显著性别差异，这可能是生存差异的原因。男性较长的诊断期可能导致其较低的生存率。这些结果凸显了采取针对性干预措施以减少这些差异并改善患者预后的必要性。
