Waibel Jill S, Schallen Konika Patel
Miami Dermatology and Laser Institute, Miami, Florida, USA.
Candela Institute for Excellence, Marlborough, Massachusetts, USA.
Lasers Surg Med. 2025 Jan;57(1):63-70. doi: 10.1002/lsm.23866. Epub 2025 Jan 24.
The non-ablative 1940-nm laser induces controlled thermal damage at superficial depths without ablating the epidermis.
We evaluated a new 1940-nm fractional diode laser for improving pigmentation and skin texture.
Participants with mild to severe benign pigmented lesions received up to three laser treatments. Blinded evaluation of randomized pretreatment versus 1-month posttreatment photos was conducted by three independent dermatologists to identify the correct posttreatment image and assess pigmentation on a 5-point scale (0 = 0% improvement, 4 = 75%-100% improvement) and skin texture improvement.
Fifty-four subjects (50 females; Fitzpatrick skin types I-IV) with pigmented lesions on the face or body underwent a total of 172 treatments. Blinded evaluation of 45 photography sets resulted in a 91% success rate of correct identification of posttreatment photos with a mean pigmentation improvement score of 2.0 (p < 0.05) and improvement in skin texture for 62% of treated areas. Mild to moderate edema (70%) and erythema (88%) were observed immediately posttreatment. Trace melasma recurrence in three subjects and one case of mild rash resolved during the study.
Non-ablative fractional 1940-nm diode laser skin resurfacing is safe and effective at improving overall skin quality and treating pigmentation after 2-3 treatments. Long-term follow-up of clinical outcome is warranted.
非剥脱性1940纳米激光可在不剥脱表皮的情况下在浅表深度诱导可控的热损伤。
我们评估了一种新型1940纳米分数二极管激光在改善色素沉着和皮肤质地方面的效果。
患有轻至重度良性色素沉着病变的参与者接受了多达三次激光治疗。由三名独立的皮肤科医生对随机分组的治疗前与治疗后1个月的照片进行盲法评估，以确定正确的治疗后图像，并采用5分制评估色素沉着情况（0 = 无改善，4 = 改善75%-100%）以及皮肤质地改善情况。
54名受试者（50名女性；Fitzpatrick皮肤分型I-IV型）面部或身体有色素沉着病变，共接受了172次治疗。对45组照片进行盲法评估，正确识别治疗后照片的成功率为91%，色素沉着改善平均评分为2.0（p < 0.05），62%的治疗区域皮肤质地得到改善。治疗后即刻观察到轻度至中度水肿（70%）和红斑（88%）。在研究期间，三名受试者出现微量黄褐斑复发，一例轻度皮疹消退。
非剥脱性分数1940纳米二极管激光皮肤磨削术在进行2-3次治疗后，对于改善整体皮肤质量和治疗色素沉着是安全有效的。有必要对临床结果进行长期随访。
