同源盒C4转录因子促进脂肪组织产热。

Yang Ting, Wang Yuxuan, Li Hang, Shi Fengshou, Xu Siqi, Wu Yingting, Xin Jiaqi, Liu Yi, Jiang Mengxi

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Diabetes. 2025 Apr 1;74(4):472-485. doi: 10.2337/db24-0675.

Homeobox C4 (HOXC4) links metabolic pathways and correlates inversely with mouse body weight and positively with Ucp1 expression in mouse adipose tissue. Gain- and loss-of-function experiments in mice demonstrated HOXC4's essential role in promoting adipose thermogenesis and providing metabolic benefits. HOXC4 interacts with the nuclear receptor coactivator 1 cofactor via its hexapeptide motif to activate Ucp1 transcription, revealing a novel mechanism of thermogenic gene regulation.

同源盒C4（HOXC4）连接代谢途径，与小鼠体重呈负相关，与小鼠脂肪组织中的Ucp1表达呈正相关。在小鼠中进行的功能获得和功能丧失实验表明，HOXC4在促进脂肪产热和提供代谢益处方面起着至关重要的作用。HOXC4通过其六肽基序与核受体辅激活因子1辅因子相互作用，以激活Ucp1转录，揭示了一种产热基因调控的新机制。