Navarro M, Espinosa L, Alvarez Coca J, Peña A, Larrauri M
An Esp Pediatr. 1985 Jan;22(1):5-11.
A group of 39 girls with urinary tract infection are studied to analyse the clinical findings, response to treatment and natural history of the disease. All of them had more than three episodes of infection per year and renal function and initial cysto-urographic study were normal. Mean age at diagnosis was 4.8 years and the mean follow-up 3.4 years. In 7.6% of cases familial incidence was observed. During infection free periods, 35.8% of patients had urinary incontinence. 25% of recurrences were asymptomatic. Only one case developed during the follow-up a unilateral polar scar associated with grave II vesicoureteral reflux. Recurrence rate/girl/year, decrease from 3.8 during the first year to 1.5 at 5th year of follow-up. Patients who received prophylaxis with nitrofurantoin showed a clear decrease in rate of recurrence.
对39名患有尿路感染的女孩进行了研究，以分析该疾病的临床症状、治疗反应及自然病程。她们均每年感染超过3次，且肾功能及初始膀胱尿道造影检查均正常。诊断时的平均年龄为4.8岁，平均随访时间为3.4年。7.6%的病例观察到有家族发病率。在无感染期，35.8%的患者有尿失禁。25%的复发是无症状的。随访期间仅1例出现与严重II级膀胱输尿管反流相关的单侧极部瘢痕。复发率/女孩/年，从第一年的3.8降至随访第5年的1.5。接受呋喃妥因预防治疗的患者复发率明显降低。
