Labbé J
Can Med Assoc J. 1984 Nov 15;131(10):1229-33.
Two types of prophylaxis of urinary tract infection with trimethoprim-sulfamethoxazole (TMP-SMZ) were studied in 72 children with recurrent urinary tract infections or vesicoureteral reflux or both. Daily prophylaxis only was used in 36 children and thrice-weekly prophylaxis only in 25 others, and 11 children received successively both types of prophylaxis. The same dosage was used in all cases: 2 mg/kg of TMP and 10 mg/kg of SMZ, given at bedtime. With daily prophylaxis the infection rate over 556 patient-months was 5.4 cases per 1000 patient-months, compared with 285.4 cases in the year before prophylaxis; side effects were noted in 11% of the patients during treatment. With thrice-weekly prophylaxis the infection rate over 381 patient-months was 15.7 cases per 1000 patient-months, compared with 313.6 cases in the year before prophylaxis; only 3% of the patients receiving this treatment had a side effect that was possibly drug-related. These results indicate that effective prophylaxis of urinary tract infection in children can be obtained with these two types of treatment.
在72例患有复发性尿路感染、膀胱输尿管反流或两者皆有的儿童中，研究了两种使用甲氧苄啶-磺胺甲恶唑（TMP-SMZ）预防尿路感染的方法。36例儿童仅采用每日预防用药，另外25例仅采用每周三次预防用药，11例儿童先后接受了两种预防方法。所有病例均使用相同剂量：2mg/kg甲氧苄啶和10mg/kg磺胺甲恶唑，睡前服用。每日预防用药时，在556个患者月期间，感染率为每1000患者月5.4例，而预防用药前一年为285.4例；治疗期间11%的患者出现副作用。每周三次预防用药时，在381个患者月期间，感染率为每1000患者月15.7例，而预防用药前一年为313.6例；接受该治疗的患者中只有3%出现了可能与药物相关的副作用。这些结果表明，这两种治疗方法均可有效预防儿童尿路感染。
