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Spatial distribution of immune cells and their proximity to STING cells are associated with survival in glioblastoma.

作者信息

Jeon Hanwool, Kang Hayeong, Im Jihyun, Jo Suin, Jung Hyunchul, Kim Moinay, Kim Jae Hyun, Lee Eunyeup, Kim Soyoung, Kim Jeong Hoon, Hong Chang-Ki, Kim Young-Hoon, Song Sang Woo, Park Jinha, Kim Sang-Yeob, Lee Seungjoo

机构信息

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Translational Biomedical Research Group, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.

出版信息

Clin Transl Med. 2025 Feb;15(2):e70187. doi: 10.1002/ctm2.70187.

DOI:10.1002/ctm2.70187
PMID:39856469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11761387/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/a244adc69f8e/CTM2-15-e70187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/e89dc386846a/CTM2-15-e70187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/c88d294cb3cf/CTM2-15-e70187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/a244adc69f8e/CTM2-15-e70187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/e89dc386846a/CTM2-15-e70187-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/c88d294cb3cf/CTM2-15-e70187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d05/11761387/a244adc69f8e/CTM2-15-e70187-g002.jpg

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Spatial distribution of immune cells and their proximity to STING cells are associated with survival in glioblastoma.免疫细胞的空间分布及其与STING细胞的接近程度与胶质母细胞瘤的生存率相关。
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本文引用的文献

1
STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma.STING 激动剂 8803 重编程免疫微环境,增加胶质母细胞瘤临床前模型中的存活率。
J Clin Invest. 2024 Jun 17;134(12):e175033. doi: 10.1172/JCI175033.
2
Endothelial type I interferon response and brain diseases: identifying STING as a therapeutic target.内皮细胞I型干扰素反应与脑部疾病:将干扰素基因刺激蛋白确定为治疗靶点
Front Cell Dev Biol. 2023 Sep 14;11:1249235. doi: 10.3389/fcell.2023.1249235. eCollection 2023.
3
The cGAS-STING pathway and cancer.
cGAS-STING 通路与癌症。
Nat Cancer. 2022 Dec;3(12):1452-1463. doi: 10.1038/s43018-022-00468-w. Epub 2022 Dec 12.
4
Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.表观遗传沉默信号调节蛋白(STING)在胶质瘤中具有发育保守性,并且可以通过甲基转移酶抑制作用得到挽救。
Cancer Cell. 2022 May 9;40(5):439-440. doi: 10.1016/j.ccell.2022.04.009. Epub 2022 Apr 28.
5
Endothelial STING controls T cell transmigration in an IFNI-dependent manner.内皮细胞 STING 通过 IFNI 依赖性方式控制 T 细胞迁移。
JCI Insight. 2021 Aug 9;6(15):e149346. doi: 10.1172/jci.insight.149346.
6
The Human Protein Atlas-Spatial localization of the human proteome in health and disease.人类蛋白质图谱——人类蛋白质组在健康和疾病中的空间定位。
Protein Sci. 2021 Jan;30(1):218-233. doi: 10.1002/pro.3987. Epub 2020 Nov 13.
7
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.新辅助抗 PD-1 免疫治疗在复发性胶质母细胞瘤中促进了肿瘤内和全身免疫应答,并带来生存获益。
Nat Med. 2019 Mar;25(3):477-486. doi: 10.1038/s41591-018-0337-7. Epub 2019 Feb 11.
8
Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4 T-lymphocyte counts.ERC1671联合贝伐单抗对比贝伐单抗联合安慰剂治疗复发性胶质母细胞瘤的II期研究:中期结果及与CD4 T淋巴细胞计数的相关性
CNS Oncol. 2018 Jul 1;7(3):CNS22. doi: 10.2217/cns-2018-0009. Epub 2018 Aug 29.
9
Current state of immunotherapy for glioblastoma.胶质母细胞瘤的免疫治疗现状。
Nat Rev Clin Oncol. 2018 Jul;15(7):422-442. doi: 10.1038/s41571-018-0003-5.