载脂蛋白E ε4状态与阿尔茨海默病风险之间的关联：一项荟萃分析。

Association between apolipoprotein E ε4 status and the risk of Alzheimer's disease: a meta-analysis.

作者信息

Ren Zijun, Guan Zhenting, Guan Qingliang, Guan Hongjian, Che Huiying

机构信息

Department of Neurology, Yanbian University hospital, City of Yanji, Jilin Province, China.

Department of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

BMC Neurosci. 2025 Jan 24;26(1):5. doi: 10.1186/s12868-024-00914-8.

DOI:10.1186/s12868-024-00914-8

PMID:39856540

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11761182/

Abstract

BACKGROUND

The apolipoprotein E ε4 (APOE ε4) status has a controversial role in predicting Alzheimer's disease (AD) factors. This meta-analysis assessed AD event risk in patients with APOE ε4 status.

MATERIALS AND METHODS

The relevant English-language articles were identified by searching the Cochrane Library, EMBASE, and PubMed databases. The prognostic significance of APOE ε4 status in AD patients was examined on the basis of pooled hazard ratios (HRs).

RESULTS

A total of 22 studies published after 1987, including 571,800 patients, were included. Consequently, APOE ε4 status was a risk factor for disease-free survival (DFS, HR = 2.033; 95% confidence interval [CI] = 1.589-2.602; P = 0.000; I 2 = 93.1%) in patients with AD. Additionally, subgroup analysis suggested that the ROC curve was the main risk factor among patients with AD.

CONCLUSIONS

AD patients with different events are managed via different methods; however, the present meta-analysis suggests an increased risk of AD events in patients with different APOE ε4 statuses.

摘要

背景

载脂蛋白Eε4（APOEε4）状态在预测阿尔茨海默病（AD）因素方面的作用存在争议。本荟萃分析评估了APOEε4状态患者发生AD事件的风险。

材料与方法

通过检索Cochrane图书馆、EMBASE和PubMed数据库确定相关英文文章。基于合并风险比（HR）研究了APOEε4状态在AD患者中的预后意义。

结果

纳入了1987年后发表的共22项研究，包括571800名患者。因此，APOEε4状态是AD患者无病生存期（DFS，HR = 2.033；95%置信区间[CI] = 1.589 - 2.602；P = 0.000；I2 = 93.1%）的危险因素。此外，亚组分析表明ROC曲线是AD患者中的主要危险因素。