体育活动对处于绝经过渡和绝经阶段女性抑郁和焦虑症状的影响：随机对照试验的综合系统评价与荟萃分析
Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomized controlled trials.
作者信息
Yue Hongyu, Yang Yijiao, Xie Fangfang, Cui Jiahe, Li Yang, Si Mengran, Li Shanshan, Yao Fei
机构信息
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shanghai Minhang Hospital of Intergrated Traditional Chinese and Western Medicine, Shanghai, China.
出版信息
Int J Behav Nutr Phys Act. 2025 Jan 24;22(1):13. doi: 10.1186/s12966-025-01712-z.
BACKGROUND
Depression and anxiety may significantly affect women in the menopausal transition and menopause. In addition to traditional treatment strategies such as hormone therapy, antidepressants, and psychotherapy, physical activity (PA) have been increasingly studied, but there is no consensus about their role in menopausal women with depression and anxiety.
OBJECTIVE
The current study aimed to evaluate the effect of PA on the severity of depressive (DS) and anxiety (AS) symptoms in women during the menopausal transition and menopause.
METHODS
We searched for relevant published studies in PubMed, Embase, Web of Science, Cochrane Library, and CINAHL prior to 8 April 2024, focusing on randomized controlled trials documenting the effect of physical activity on DS and AS, and assessed study quality using the Newcastle-Ottawa Scale.
RESULTS
The data used for meta-analysis were derived from 21 studies (DS, n = 9; AS, n = 1; DS and AS combined, n = 11) involving 2020 participants. The results showed that PA groups demonstrated a statistically significant effect of depressive symptoms versus controls (DS [SMD: -0.66, 95% CI: -0.99 to -0.33; P < 0.001]; AS [SMD: -0.55, 95% CI: -0.82 to -0.27; P < 0.001]). As subgroup analyses demonstrated, physical exercise also reduced depressive symptom of women in menopausal status (SMD =-0.56, 95% CI: -0.96 to - 0.17, p = 0.006, I = 69%), postmenopausal status (SMD =-0.94, 95% CI: -1.46 to - 0.42, p = 0.0004, I = 94%), and both in menopausal transition and postmenopausal status (SMD =-0.30, 95% CI: -0.49 to - 0.12, p = 0.001, I = 0%), while it only reduced anxiety symptom of postmenopausal women (SMD =-0.96, 95% CI: -1.49 to - 0.43, p = 0.0004, I = 89%). Low-intensity and moderate-intensity exercise both produced increasingly benefits over depressive and anxiety symptoms. However, there is no statistically significant effect of exercise intensity on both depressive symptom and anxiety symptom.
CONCLUSION
Physical activities with low to moderate intensity can impart remarkable improvements for managing menopausal women with depression and anxiety.
背景
抑郁和焦虑可能会对处于围绝经期和绝经后的女性产生重大影响。除了激素疗法、抗抑郁药和心理治疗等传统治疗策略外，体育活动（PA）也越来越受到研究，但对于其在患有抑郁和焦虑的绝经后女性中的作用尚无共识。
目的
本研究旨在评估体育活动对处于围绝经期和绝经后的女性抑郁症状严重程度（DS）和焦虑症状严重程度（AS）的影响。
方法
我们在2024年4月8日前检索了PubMed、Embase、Web of Science、Cochrane图书馆和CINAHL中相关的已发表研究，重点关注记录体育活动对DS和AS影响的随机对照试验，并使用纽卡斯尔-渥太华量表评估研究质量。
结果
用于荟萃分析的数据来自21项研究（DS，n = 9；AS，n = 1；DS和AS合并，n = 11），涉及2020名参与者。结果表明，与对照组相比，PA组在抑郁症状方面显示出统计学上的显著效果（DS [标准化均数差：-0.66，95%置信区间：-0.99至-0.33；P < 0.001]；AS [标准化均数差：-0.55，95%置信区间：-0.82至-0.27；P < 0.001]）。亚组分析表明，体育锻炼也减轻了处于绝经状态女性的抑郁症状（标准化均数差 = -0.56，95%置信区间：-0.96至-0.17，p = 0.006，I² = 69%）、绝经后状态女性的抑郁症状（标准化均数差 = -0.94，95%置信区间：-1.46至-0.42，p = 0.0004，I² = 94%）以及处于围绝经期和绝经后状态女性的抑郁症状（标准化均数差 = -0.30，95%置信区间：-0.49至-0.12，p = 0.
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