Department of Obstetrics and Gynecology, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey.
J Psychosom Obstet Gynaecol. 2022 Dec;43(4):482-487. doi: 10.1080/0167482X.2022.2069008. Epub 2022 May 8.
To assess sleep disturbances, levels of anxiety, depression and fatigue in women with premature ovarian insufficiency (POI).
The study included 62 women with POI and 62 age-matched controls. Women in both groups completed questionnaires. Pittsburgh Sleep Quality Index, Insomnia severity index, Epworth Sleepiness Scale, Hospital Anxiety and Depression Scale and Fatigue Severity Scale were used.
We found poor sleep quality, higher levels of insomnia in women with POI than in controls. Depression was much more prevalent and severe in POI women. Total anxiety score, the severity of anxiety and fatigue did not differ significantly between the groups. According to the multivariable logistic regression analysis, being married and having POI were associated with worse quality of sleep, and having more children was associated with an increase in depression levels in the whole cohort. Backward analysis showed that when POI status was taken as a reference, married women were at 6.5 fold increased risk of poor sleep quality.
Women with premature ovarian failure are more likely to suffer from poor sleep quality, insomnia and depression than healthy women.
评估卵巢早衰（POI）女性的睡眠障碍、焦虑、抑郁和疲劳水平。
本研究纳入了 62 名 POI 女性和 62 名年龄匹配的对照组女性。两组女性均完成了问卷调查。使用匹兹堡睡眠质量指数、失眠严重程度指数、Epworth 嗜睡量表、医院焦虑和抑郁量表以及疲劳严重程度量表。
我们发现 POI 女性的睡眠质量较差，失眠程度较对照组更高。POI 女性的抑郁更为普遍且严重。焦虑总分、焦虑严重程度和疲劳程度在两组间无显著差异。根据多变量逻辑回归分析，已婚和 POI 与睡眠质量较差相关，而孩子数量较多与整个队列的抑郁水平升高相关。向后分析显示，当以 POI 状态为参照时，已婚女性的睡眠质量较差的风险增加 6.5 倍。
与健康女性相比，卵巢早衰的女性更有可能出现睡眠质量差、失眠和抑郁。
