Yin Huihui, Yu Jie, Chen Yunzhao
Cancer Center, Department of Pathology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, Zhejiang, 310014, China.
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang, 310014, People's Republic of China.
World J Surg Oncol. 2025 Jan 24;23(1):20. doi: 10.1186/s12957-025-03682-9.
Low-grade mucinous neoplasms typically originate from the appendix and are characterized by a lining of low-grade mucus-secreting columnar epithelial cells and smooth muscle. However, atypical origins can occur, as demonstrated in this case report.
We present a case involving a 33-year-old male who, upon physical examination, was found to have an abdominal mass. A computed tomography (CT) scan revealed a cystic mass located between the pancreatic tail and the adjacent bowel duct, with significant enhancement of the cyst wall observed on contrast-enhanced imaging. The patient subsequently underwent laparoscopic surgical resection of the mass, and the resected specimen was sent for pathological evaluation. The pathology results were consistent with the histological morphology and immunohistochemical characteristics of low-grade mucinous tumors arising from intestinal duplication. Three and a half years post-resection, the patient returned for a follow-up examination, during which abdominal CT and blood tumor markers indicated no signs of tumor recurrence.
While low-grade mucinous tumors predominantly originate from the appendix, this case illustrates an unusual occurrence of such neoplasms arising from intestinal duplication. This report aims to enhance clinical awareness of low-grade mucinous tumors originating from intestinal duplication, thereby improving the rates of preoperative diagnosis and reducing instances of misdiagnosis.
低级别黏液性肿瘤通常起源于阑尾，其特征为内衬低级别黏液分泌柱状上皮细胞和平滑肌。然而，非典型起源也可能发生，本病例报告即展示了这一点。
我们报告一例33岁男性病例，该患者在体格检查时发现腹部有肿块。计算机断层扫描（CT）显示胰腺尾部与相邻肠管之间有一个囊性肿块，增强扫描可见囊肿壁明显强化。患者随后接受了肿块的腹腔镜手术切除，并将切除标本送去做病理评估。病理结果与肠重复畸形引起的低级别黏液性肿瘤的组织形态学和免疫组化特征相符。切除术后三年半，患者返回进行随访检查，腹部CT和血液肿瘤标志物检查均未显示肿瘤复发迹象。
虽然低级别黏液性肿瘤主要起源于阑尾，但本病例说明了这种肿瘤由肠重复畸形引起的不寻常情况。本报告旨在提高对肠重复畸形起源的低级别黏液性肿瘤的临床认识，从而提高术前诊断率并减少误诊情况。
