Hay J, Graham D I, Hutchison W M, Siim J C
Ann Trop Med Parasitol. 1985 Feb;79(1):21-9. doi: 10.1080/00034983.1985.11811885.
A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
本文报道了对子宫内感染弓形虫并出现眼部弓形虫病表现的成年小鼠大脑进行的组织病理学研究。所有大脑均含有弓形虫组织囊肿。亚急性/慢性脑膜脑炎是大脑炎症反应的主要特征。显微镜下特征表明自身免疫过程可能在该疾病中起作用。我们认为，我们的小鼠模型将为研究先天性弓形虫感染导致的中枢神经系统组织病理学过程提供一个简单且廉价的工具。
