Central Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.
Cancer Med. 2024 Jun;13(12):e7285. doi: 10.1002/cam4.7285.
ATP-binding cassette subfamily G member 1 is mostly known as a transporter for intracellular cholesterol efflux, and a number of studies indicate that ABCG1 also functions actively in tumor initiation and progression. This review aimed to provide an overall review of how ABCG1 acts in tumor progression.
A comprehensive searching about ABCG1 and tumor was conducted up to November 2023 using proper keywords through databases including PubMed and Web of Science.
Overall, ABCG1 plays a crucial role in the development of multiple tumorigenesis. ABCG1 enhances tumor-promoting ability through conferring stem-like properties to cancer cells and mediates chemoresistance in multiple cancers. Additionally, ABCG1 may act as a kinase to phosphorylate downstream molecules and induces tumor growth. In tumor microenvironment, ABCG1 plays a substantial role in immunity response through macrophages to create a tumor-favoring circumstance.
High expression of ABCG1 is usually associated with poor prognosis, which means ABCG1 may be a potential biomarker for early diagnosis and prognosis of various cancers. ABCG1-targeted therapy may provide a novel treatment for cancer patients.
ATP 结合盒亚家族 G 成员 1（ABCG1）通常被认为是细胞内胆固醇外流的转运蛋白，许多研究表明 ABCG1 也在肿瘤起始和进展中积极发挥作用。本综述旨在全面回顾 ABCG1 在肿瘤进展中的作用。
截至 2023 年 11 月，使用 PubMed 和 Web of Science 等数据库中适当的关键字，对 ABCG1 和肿瘤进行了全面检索。
总体而言，ABCG1 在多种肿瘤发生发展中起着关键作用。ABCG1 通过赋予癌细胞干细胞样特性来增强肿瘤促进能力，并介导多种癌症的化疗耐药性。此外，ABCG1 可能作为激酶磷酸化下游分子，诱导肿瘤生长。在肿瘤微环境中，ABCG1 通过巨噬细胞在免疫反应中发挥重要作用，从而创造有利于肿瘤的环境。
ABCG1 的高表达通常与预后不良相关，这意味着 ABCG1 可能是各种癌症早期诊断和预后的潜在生物标志物。ABCG1 靶向治疗可能为癌症患者提供新的治疗方法。
