Tamayo-Trujillo Rafael, Guevara-Ramírez Patricia, Cadena-Ullauri Santiago, Ruiz Pozo Viviana A, Paz-Cruz Elius, Zambrano Ana Karina
Universidad UTE, Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Quito, Ecuador.
Front Pharmacol. 2025 Jul 17;16:1621163. doi: 10.3389/fphar.2025.1621163. eCollection 2025.
Statins have been primarily used for the management of low-density lipoprotein cholesterol and cardiovascular diseases However, in recent years, research has identified potential applications beyond cholesterol regulation. Statins exhibit pleiotropic effects, due to their ability to modulate gene expression via epigenetic mechanisms, including DNA methylation, histone acetylation, and microRNA regulation. Clinical studies have correlated these epigenetic changes with various pathological conditions, such as inflammation, atherosclerosis, cancer, diabetes, and autoimmune disorders. Despite encouraging findings, further research is required to fully understand the molecular pathways associated with the epigenetic actions of statins and disease pathogenesis. This review describes the potential role of statins as epigenetic modulators and their relevance in human disease management.
他汀类药物主要用于管理低密度脂蛋白胆固醇和心血管疾病。然而，近年来，研究发现了其在胆固醇调节之外的潜在应用。他汀类药物具有多效性，因为它们能够通过表观遗传机制调节基因表达，包括DNA甲基化、组蛋白乙酰化和微小RNA调节。临床研究已将这些表观遗传变化与各种病理状况相关联，如炎症、动脉粥样硬化、癌症、糖尿病和自身免疫性疾病。尽管有令人鼓舞的发现，但仍需要进一步研究以充分了解与他汀类药物表观遗传作用和疾病发病机制相关的分子途径。本综述描述了他汀类药物作为表观遗传调节剂的潜在作用及其在人类疾病管理中的相关性。
