Schweisguth O
Arch Fr Pediatr. 1985 Jan;42(1):3-9.
The 476 children treated for solid malignant tumor from 1947 to 1968 at the Institut Gustave-Roussy, and living NED at 5 years, were reviewed after 5 to 36 years of follow-up (median 17 years). Two children were affected in the sibship in 9 families. Thirty patients died after 7 to 32 years, 15 from late evolution of their primary tumor, 7 from second cancer, and 8 from other causes. Late sequellae (3 lethal), mainly neurologic, orthopedic, endocrine, and others were observed in 271 patients, and not known in 48. A second tumor (19 malignant, 46 benign) occurred from 7 to 26 years after treatment, more than half in the previously irradiated area. These patients have presently 164 known children; two died in infancy, two have malformations. None has had tumor up until now. The long-term cure of cancer remains true in 95% of cases in our span of follow-up, with sequellae compatible with a useful life in most cases.
1947年至1968年在古斯塔夫 - 鲁西研究所接受实体恶性肿瘤治疗且5年后无疾病证据（NED）存活的476名儿童，在随访5至36年（中位随访时间17年）后接受了复查。9个家庭中有两个家庭的同胞中有两名儿童患病。30名患者在7至32年后死亡，15名死于原发肿瘤的晚期进展，7名死于第二癌症，8名死于其他原因。271名患者出现晚期后遗症（3例致死），主要为神经、骨科、内分泌及其他方面的后遗症，48名患者无相关后遗症。治疗后7至26年出现了第二种肿瘤（19例恶性，46例良性），其中一半以上出现在先前接受过放疗的区域。这些患者目前有164名已知子女；两名在婴儿期死亡，两名有畸形。到目前为止，没有人患肿瘤。在我们的随访期间，95%的病例实现了癌症的长期治愈，大多数情况下后遗症与正常生活相容。
