Oberlin O, Bernard A, Flamant F, Hartmann O, Kalifa C, Patte C, Sarrazin D, Tournade M F, Lemerle J
Arch Fr Pediatr. 1984 Apr;41(4):241-8.
Thirty-eight children, followed in the pediatric Department of Institut Gustave-Roussy, developed second malignant neoplasms. Intervals between the two neoplasms ranged from 1 to 26 years. The second neoplasms were defined as having a different histologic diagnosis than the first ones: osteosarcoma, fibrosarcoma, thyroid carcinoma, leukemia were the most frequent second neoplasms. The potential carcinogenic part of chemotherapy and radiotherapy is emphasized. In addition, some genetic susceptibility may enhance the carcinogenic effects of therapy. Nevertheless the incidence of second malignant neoplasms is low. Its estimation is discussed here.
在古斯塔夫-鲁西研究所儿科接受随访的38名儿童患上了第二种恶性肿瘤。两种肿瘤之间的间隔时间为1至26年。第二种恶性肿瘤的组织学诊断与第一种不同：骨肉瘤、纤维肉瘤、甲状腺癌、白血病是最常见的第二种恶性肿瘤。强调了化疗和放疗潜在的致癌作用。此外，一些遗传易感性可能会增强治疗的致癌效果。然而，第二种恶性肿瘤的发病率较低。本文对其评估进行了讨论。
