Martínez-García Irene, Saz-Lara Alicia, Pascual-Morena Carlos, Díez-Fernández Ana, Valladolid-Ayllón Sara, Bizzozero-Peroni Bruno, Martínez-Cifuentes Óscar, Rodríguez-Gutiérrez Eva, Cavero-Redondo Iván
CarVasCare Research Group, Facultad de Enfermería de Cuenca, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain.
Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain.
Biomedicines. 2025 Jan 8;13(1):137. doi: 10.3390/biomedicines13010137.
: Poor metabolic control is associated with increased levels of advanced glycation end products (AGEs), which in turn may lead to increased arterial stiffness. The aim of this study was to estimate the association between glycated haemoglobin A1c (HbA1c) and aortic pulse wave velocity (a-PWV) in healthy subjects and to analyse the mediating effect of AGEs measured by skin autofluorescence (SAF) on this association. : HbA1c, a-PWV and SAF were analysed in 390 healthy Spanish subjects from the EVasCu study (42.02 ± 13.14 years, 63.08% females). A directed acyclic graph (DAG) was generated to define the covariates to be included, and the model was confirmed via multiple linear regression analysis. Descriptive and exploratory analyses were performed to investigate the associations between variables. Finally, adjusted and unadjusted mediation analyses were performed to verify the influence of SAF on the main association between HbA1c and a-PWV. : Multiple linear regression analyses for a-PWV supported the validity of the structure in the DAG. Descriptive and exploratory analyses revealed that when the models were adjusted to include all covariates, the statistical significance of the main association disappeared. Mediation analysis revealed that SAF mediated 35.77% of the effect of HbA1c on a-PWV in the unadjusted model and 42.18% after adjusting for covariates. : Our study suggests that increases in HbA1c levels are associated with increases in a-PWV and that this relationship is mediated by the SAF score in healthy adults.
代谢控制不佳与晚期糖基化终产物（AGEs）水平升高有关，而这反过来可能导致动脉僵硬度增加。本研究的目的是评估健康受试者糖化血红蛋白A1c（HbA1c）与主动脉脉搏波速度（a-PWV）之间的关联，并分析通过皮肤自发荧光（SAF）测量的AGEs对这种关联的中介作用。：对来自EVasCu研究的390名健康西班牙受试者（42.02±13.14岁，63.08%为女性）进行了HbA1c、a-PWV和SAF分析。生成了一个有向无环图（DAG）来定义要纳入的协变量，并通过多元线性回归分析对模型进行了确认。进行了描述性和探索性分析以研究变量之间的关联。最后，进行了调整和未调整的中介分析，以验证SAF对HbA1c与a-PWV之间主要关联的影响。：对a-PWV的多元线性回归分析支持了DAG中结构的有效性。描述性和探索性分析表明，当模型调整为纳入所有协变量时，主要关联的统计学意义消失。中介分析表明，在未调整的模型中，SAF介导了HbA1c对a-PWV影响的35.77%，在调整协变量后为42.18%。：我们的研究表明，HbA1c水平升高与a-PWV升高有关，并且这种关系在健康成年人中由SAF评分介导。
