Mallah Hamza, Diabasana Zania, Soultani Sina, Idoux-Gillet Ysia, Massfelder Thierry
Regenerative NanoMedicine, Centre de Recherche en Biomédecine de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), UMR_S U1260 INSERM and University of Strasbourg, 67085 Strasbourg, France.
Cancers (Basel). 2025 Jan 9;17(2):194. doi: 10.3390/cancers17020194.
Prostate cancer is one of the most common diseases among men worldwide and continues to pose a serious threat to health. This review shows the history and the new developments in the management of prostate cancer, with an emphasis on a range of therapeutic approaches, such as hormone therapy, radiation therapy, surgery, and innovative targeted therapeutics. The evolution of these treatments is examined in light of clinical outcomes, patient quality of life, and emerging resistance mechanisms, such as the recently shown vitamin D-based strategies. New developments that have the potential to increase survival rates and reduce side effects are also discussed, including PARP inhibitors (PARPis), immunotherapy, and tailored medication. Additionally, the use of biomarkers and sophisticated imaging methods in therapeutic decision-making is explored, with a focus on how these tools might improve patient care. The absolute necessity for a multidisciplinary approach for improving treatment strategies is becoming more and more apparent as our understanding of the biology of prostate cancer deepens. This approach ensures that patients receive customized medicines that fit their unique profiles. Future avenues of investigation will focus on resolving issues dealing with treatment efficacy and resistance to improve treatment results, ultimately leading to disease cure for prostate cancer patients.
前列腺癌是全球男性中最常见的疾病之一，持续对健康构成严重威胁。本综述展示了前列腺癌治疗的历史与新进展，重点介绍了一系列治疗方法，如激素疗法、放射疗法、手术以及创新的靶向疗法。根据临床结果、患者生活质量以及新出现的耐药机制（如最近显示的基于维生素D的策略）来审视这些治疗方法的演变。还讨论了有可能提高生存率并减少副作用的新进展，包括聚二磷酸腺苷核糖聚合酶抑制剂（PARPis）、免疫疗法和个体化用药。此外，探讨了生物标志物和精密成像方法在治疗决策中的应用，重点关注这些工具如何改善患者护理。随着我们对前列腺癌生物学的理解不断深入，采用多学科方法改善治疗策略的绝对必要性日益明显。这种方法可确保患者获得适合其独特情况的定制药物。未来的研究方向将聚焦于解决治疗效果和耐药性问题以改善治疗结果，最终实现前列腺癌患者的疾病治愈。
