Department of Nursing, Faculty of Medical Sciences, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Department of Laboratory Sciences, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran.
Cell Biol Int. 2023 Dec;47(12):1895-1904. doi: 10.1002/cbin.12094. Epub 2023 Oct 9.
A common type of cancer among men is the prostate cancer that kills many people every year. The multistage of this disease and the involvement of the vital organs of the body have reduced the life span and quality of life of the people involved and turned the treatment process into a complex one. NFATc1 biomarker contributes significantly in the diagnosis and treatment of this disease by increasing its expression in prostate cancer and helping the proliferation, differentiation, and invasion of cancer cells through different signaling pathways. NFATc1 is also able to target the metabolism of cancer cells by inserting specific oncogene molecules such as c-myc that it causes cell growth and proliferation. Bone is a common tissue where prostate cancer cells metastasize. In this regard, the activity of NFATc1, through the regulation of different signaling cascades, including the RANKL/RANK signaling pathway, in turn, increases the activity of osteoclasts, and as a result, bone tissue is gradually ruined. Using Silibinin as a medicinal plant extract can inhibit the activity of osteoclasts related to prostate cancer by targeting NFATc. Undoubtedly, NFATc1 is one of the effective oncogenes related to prostate cancer, which has the potential to put this cancer on the path of progression and metastasis. In this review, we will highlight the role of NFATc1 in the progression and metastasis of prostate cancer. Furthermore, we will summarize signaling pathways and molecular mechanism, through which NFATc1 regulates the process of prostate cancer.
一种常见的男性癌症是前列腺癌，每年导致许多人死亡。这种疾病的多阶段发展和身体重要器官的参与，降低了患者的寿命和生活质量，并使治疗过程变得复杂。NFATc1 生物标志物通过增加前列腺癌中的表达，并通过不同的信号通路帮助癌细胞的增殖、分化和侵袭，在这种疾病的诊断和治疗中做出了重大贡献。NFATc1 还能够通过插入特定的癌基因分子，如 c-myc，来靶向癌细胞的代谢，从而导致细胞生长和增殖。骨骼是前列腺癌细胞转移的常见组织。在这方面，NFATc1 的活性通过调节不同的信号级联反应，包括 RANKL/RANK 信号通路，反过来又增加了破骨细胞的活性，结果，骨组织逐渐被破坏。使用水飞蓟素作为药用植物提取物可以通过靶向 NFAT 来抑制与前列腺癌相关的破骨细胞的活性。毫无疑问，NFATc1 是与前列腺癌相关的有效癌基因之一，它有可能使这种癌症进入进展和转移的轨道。在这篇综述中，我们将强调 NFATc1 在前列腺癌进展和转移中的作用。此外，我们将总结信号通路和分子机制，通过这些通路和机制，NFATc1 调节前列腺癌的进程。
