Zhu Shimin, Zha Musu, Xia Yanan
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
Animals (Basel). 2025 Jan 19;15(2):272. doi: 10.3390/ani15020272.
Cats are popular companions for humans, and their health is of importance to a growing number of pet owners. The juvenile period is a critical stage of cat growth; in particular, the metabolic activity of the intestinal microbiome of kittens is critical for processing nutrients and supporting overall health. In this study, the effect of complex probiotics on the intestinal health of kittens was explored through a metabolomics analysis. Twenty-four healthy kittens were randomly assigned to two groups ( = 12): the control group was provided a basal diet and the probiotics group was provided the basal diet supplemented with complex probiotics (given at the same time daily). The kittens were acclimatized for 5 days, and the experiment was conducted for 14 days. We collected feces from each kitten on days 1 and 14 for metabolomic analyses. Compared to the control, the probiotics group had significantly higher ( < 0.05) methylmalonylcarnitine, lysyl-hydroxyproline, phenylpropionylglycine, and vitamin K3 levels, and significantly lower ( < 0.05) gamma-glutamyl-L-putrescine, cis-gondoic acid, myristic acid, 12,13-DiHOME, and glycodeoxycholic acid levels. The results of this study suggest that complex probiotics promote intestinal health in kittens by regulating changes in various metabolites in the intestine and may have a mitigating effect on intestinal inflammation.
猫是人类受欢迎的伴侣动物，它们的健康对越来越多的宠物主人来说至关重要。幼年期是猫生长的关键阶段；特别是，小猫肠道微生物群的代谢活动对于处理营养物质和维持整体健康至关重要。在本研究中，通过代谢组学分析探索了复合益生菌对小猫肠道健康的影响。将24只健康小猫随机分为两组（每组n = 12）：对照组给予基础日粮，益生菌组给予补充复合益生菌的基础日粮（每天同时给予）。小猫适应5天，实验进行14天。在第1天和第14天从每只小猫收集粪便进行代谢组学分析。与对照组相比，益生菌组的甲基丙二酸肉碱、赖氨酰羟脯氨酸、苯丙酰甘氨酸和维生素K3水平显著更高（P < 0.05），而γ-谷氨酰-L-腐胺、顺式-贡多酸、肉豆蔻酸、12,13-二羟基十八碳二烯酸和甘氨脱氧胆酸水平显著更低（P < 0.05）。本研究结果表明，复合益生菌通过调节肠道内各种代谢物的变化来促进小猫的肠道健康，并且可能对肠道炎症有缓解作用。
