Zhu Shimin, Guo Zhengrong, Liu Lin, Gao Yuan, Bai Lu, Chen Yongfu, Zha Musu
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.
Microorganisms. 2025 Mar 1;13(3):563. doi: 10.3390/microorganisms13030563.
The early developmental phase is a critical window for feline growth, during which immature digestive systems are susceptible to microbiome imbalances caused by environmental stressors. Our research employed macrogenomic analysis to evaluate how complex probiotic formulations influence growth metrics and gastrointestinal flora in juvenile felines. Two dozen healthy kittens were equally divided into the control group and the probiotics group following a 5-day environmental adaptation phase. Fecal scores were recorded daily for all kittens. Fresh fecal samples were collected on days 1 and 14 for macrogenomic analysis. The results showed a significantly lower rate of constipation in the probiotics group compared to the control group ( < 0.05). However, no significant differences were observed in intestinal microbial diversity or structure between the two groups. Metagenomic analysis revealed a higher relative abundance of in the probiotics group compared to the control group ( < 0.05). Additionally, the probiotics group exhibited lower relative abundances of , , and compared to the control group ( < 0.05). These results suggest that complex probiotics can regulate the intestinal microbiota, improve constipation, and promote intestinal health in kittens.
早期发育阶段是猫生长的关键时期，在此期间，未成熟的消化系统容易受到环境压力源导致的微生物群失衡的影响。我们的研究采用宏基因组分析来评估复杂的益生菌制剂如何影响幼猫的生长指标和胃肠道菌群。在经过5天的环境适应期后，将24只健康小猫平均分为对照组和益生菌组。每天记录所有小猫的粪便评分。在第1天和第14天采集新鲜粪便样本进行宏基因组分析。结果显示，与对照组相比，益生菌组的便秘发生率显著降低（<0.05）。然而，两组之间在肠道微生物多样性或结构方面未观察到显著差异。宏基因组分析显示，与对照组相比，益生菌组中[具体微生物名称1]的相对丰度更高（<0.05）。此外，与对照组相比，益生菌组中[具体微生物名称2]、[具体微生物名称3]和[具体微生物名称4]的相对丰度较低（<0.05）。这些结果表明，复杂的益生菌可以调节小猫的肠道微生物群，改善便秘，并促进肠道健康。
