Leimbach Stefanie, Nankemann Franziska, Tellen Anne, Klocke Doris, Wente Nicole, Zhang Yanchao, Krömker Volker
Department of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, Germany.
Antibiotics (Basel). 2025 Jan 2;14(1):21. doi: 10.3390/antibiotics14010021.
: Despite penicillin having a longstanding reputation as being scientifically approved for the treatment of bovine mastitis, its market share and practical application rate seem rather low. While in some countries, cases of mild and moderate mastitis are treated almost completely with simple penicillin, in other countries, penicillin is rarely used as a mono-substance in udder tubes. : Based on minimal inhibitory concentration (MIC) studies of 1489 isolates of Gram-positive microorganisms isolated from bovine mastitis cases, the extent to which penicillin preparations can fulfil their role as first-line treatment and in how many cases insufficient efficacy must be assumed was assessed in comparison with more recent studies on the achievable levels of active substances in milk. : Of the isolates, 76% had an MIC of ≤0.125 µg/mL and 95% of the isolates had an MIC of ≤1 µg/mL. : The data show that in Northern Germany, it can be assumed that penicillin is a good choice in most cases of mastitis caused by Gram-positive mastitis pathogens, at least from the perspective of antibiotic resistance.
尽管青霉素长期以来在科学上被认可用于治疗牛乳腺炎，但其市场份额和实际应用率似乎相当低。在一些国家，轻度和中度乳腺炎病例几乎完全用单纯青霉素治疗，而在其他国家，青霉素很少作为单一物质用于乳腺管。基于对从牛乳腺炎病例中分离出的1489株革兰氏阳性微生物的最低抑菌浓度（MIC）研究，与近期关于牛奶中可达到的活性物质水平的研究相比，评估了青霉素制剂作为一线治疗发挥作用的程度以及必须假定有多少病例疗效不足。在分离株中，76%的MIC≤0.125μg/mL，95%的分离株MIC≤1μg/mL。数据表明，在德国北部，可以假定青霉素在大多数由革兰氏阳性乳腺炎病原体引起的乳腺炎病例中是一个不错的选择，至少从抗生素耐药性的角度来看是这样。
