Faculty II, Microbiology, Hannover University of Applied Sciences and Arts, Hannover, Germany.
The Vale Veterinary Group, Devon, UK
Vet Rec. 2020 Nov 14;187(10):401. doi: 10.1136/vr.105674. Epub 2020 Oct 6.
Aim of the present study was to investigate the implementation of a targeted therapy (tLCT) concept under real-life circumstances, taking both pathogen-related and animal-related factors into account. The reduction of antibiotics without negative effects on cure rates was evaluated as well as the compliance by the farmers.
After analysing the existing conventional therapy (CT) concepts of five farms, the tLCT concept and a novel on-farm test were introduced. Three treatment groups were compared with respect to bacteriological cure (BC), cytological cure (CYC), full cure (FC), new infection rate (NIR), relapse rate and the treatment approach per mastitis case: the CT group, the tLCT group including all clinical mastitis (CM) cases treated according to the concept, and the modified tLCT group (tLCTmod), including the CM cases in which farmers deviated from the concept.
Even so farmers deviated from the treatment concept in 506 out of 909 cases; belonging to one of the three treatment groups had no significant impact on BC, CYC, FC, NIR or relapse rate. The antibiotic usage in the tLCT as well as in the tLCTmod group was significantly lower in comparison to the CT group.
From this, it can be deduced that farmers will reduce antibiotic doses by implementing a tLCT concept.
本研究旨在探讨在实际情况下实施靶向治疗（tLCT）概念，同时考虑病原体相关和动物相关因素。评估了在不降低治愈率的情况下减少抗生素的使用以及农民的依从性。
在分析了五家农场现有的常规治疗（CT）方案后，引入了 tLCT 方案和一项新的农场测试。比较了三个治疗组在细菌学治愈率（BC）、细胞学治愈率（CYC）、完全治愈率（FC）、新感染率（NIR）、复发率以及每例乳腺炎病例的治疗方法方面的差异：CT 组、根据概念治疗所有临床乳腺炎（CM）病例的 tLCT 组，以及偏离概念的改良 tLCT 组（tLCTmod）。
尽管如此，农民在 909 例病例中有 506 例偏离了治疗方案；属于三个治疗组之一对 BC、CYC、FC、NIR 或复发率没有显著影响。与 CT 组相比，tLCT 组和 tLCTmod 组的抗生素使用量明显减少。
由此可以推断，农民在实施 tLCT 概念时会减少抗生素剂量。
