Skeeles J K, Swafford W S, Wages D P, Hellwig H M, Slavik M F, Houghten G E, Crawford D L
Avian Dis. 1985 Jan-Mar;29(1):145-9.
Forty 6-week-old large white commercial turkeys were injected subcutaneously with a long-acting oxytetracycline formulation (69 mg/lb). The turkeys were divided into four groups of 10 birds each, and the birds in each group were bled twice at different times between 4 and 144 hours postinjection (PI) to determine serum levels of oxytetracycline. Two additional groups of turkeys were also given the long-acting oxytetracycline formulation mixed with either neomycin or a bacterin for Pasteurella multocida to determine if either of these compounds interfered with absorption of the oxytetracycline. Serum levels of oxytetracycline were 5.38 micrograms/ml, 1.59 microgram/ml, and 0.93 microgram/ml at 24, 48, and 72 hours PI, respectively, following an average dose of 69 mg/lb of body weight. These levels are all considered therapeutic. There appeared to be no interference with absorption of oxytetracycline when mixed with either neomycin or the bacterin. Tissue residues of oxytetracycline in the muscle, liver, and kidney were within tolerance levels by 3 weeks PI.
给40只6周龄的大型白色商用火鸡皮下注射长效土霉素制剂（69毫克/磅）。将火鸡分为四组，每组10只，在注射后4至144小时内的不同时间对每组火鸡采血两次，以测定血清中土霉素的水平。另外两组火鸡也注射了与新霉素或多杀巴斯德氏菌菌苗混合的长效土霉素制剂，以确定这两种化合物是否会干扰土霉素的吸收。平均体重剂量为69毫克/磅时，注射后24、48和72小时血清中土霉素水平分别为5.38微克/毫升、1.59微克/毫升和0.93微克/毫升。这些水平均被认为具有治疗作用。与新霉素或菌苗混合时，土霉素的吸收似乎未受干扰。到注射后3周时，肌肉、肝脏和肾脏中的土霉素组织残留量在耐受水平范围内。
