某油和乙醇提取物在癫痫大鼠模型中对神经炎症调节、组织病理学改变、氧化应激以及恢复表达FoxP3+的调节性T细胞平衡的治疗效果。
Therapeutic Efficacy of 's Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Balance Treg Cells Expressing FoxP3+ in a Rat Model of Epilepsy.
作者信息
Antar Aziza, Abdel-Rehiem Eman S, Al-Khalaf Areej A, Abuelsaad Abdelaziz S A, Abdel-Gabbar Mohamed, Shehab Gaber M G, Abdel-Aziz Ayman M
机构信息
Biochemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.
Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.
出版信息
Pharmaceuticals (Basel). 2024 Dec 31;18(1):35. doi: 10.3390/ph18010035.
: Despite the availability of antiepileptic drugs (AEDs) that can manage seizures, they often come with cognitive side effects. Furthermore, the role of oxidative stress and neuroinflammatory responses in epilepsy and the limitations of current AEDs necessitate exploring alternative therapeutic options. Medicinal plants, e.g., L., are rich in phenolic compounds and may provide neuroprotective and anti-inflammatory benefits. However, limited research evaluates their effectiveness in modulating neuroinflammation and histopathological changes in epilepsy models. Therefore, the current study hypothesized that treating L. extract or essential oils may reduce neuroinflammatory responses and mitigate histopathological changes in the brain, providing a natural alternative or adjunct therapy for epilepsy management. : Five groups of male Wistar rats were used: control, pilocarpine-treated epileptic, valproic acid (VPA-treated epileptic), extract, and essential oils. Numerous electrolyte levels, monoamine levels, neurotransmitter levels, and the mRNA expression of specific gate channel subtypes were evaluated in homogenate brain tissue. Additionally, histological changes in various brain regions were investigated. : The investigation revealed that the extract and essential oils obtained from L. exhibited the ability to improve the modulation of electrolytes and ions across voltage- and ligand-gated ion channels. Furthermore, it was revealed that they could decrease neuronal excitability by facilitating repolarization. Moreover, oil and ethanol extract re-balances T-reg/Th-17 cytokines, restoring the pro/anti-inflammatory cytokines and Treg markers, e.g., FOXP3 and CTLA-4, to their normal level. : The present work confirms that the extract and essential oils of L. have different activities to ameliorate the progression of histopathological alterations. Therefore, when used in conjunction with other AEDs, the extract and essential oils of can slow the progression of epileptogenesis.
尽管有能控制癫痫发作的抗癫痫药物（AEDs），但它们常常伴有认知方面的副作用。此外，氧化应激和神经炎症反应在癫痫中的作用以及当前AEDs的局限性使得有必要探索其他治疗选择。药用植物，例如[植物名称未给出]，富含酚类化合物，可能具有神经保护和抗炎益处。然而，评估它们在调节癫痫模型中的神经炎症和组织病理学变化方面有效性的研究有限。因此，当前的研究假设，用[植物名称未给出]提取物或精油进行治疗可能会减少神经炎症反应并减轻大脑中的组织病理学变化，为癫痫管理提供一种天然的替代或辅助疗法。：使用了五组雄性Wistar大鼠：对照组、毛果芸香碱诱发癫痫组、丙戊酸（VPA）治疗癫痫组、[植物名称未给出]提取物组和精油组。在匀浆脑组织中评估了多种电解质水平、单胺水平、神经递质水平以及特定门控通道亚型的mRNA表达。此外，还研究了各个脑区的组织学变化。：研究表明，从[植物名称未给出]中获得的提取物和精油具有改善跨电压门控和配体门控离子通道的电解质和离子调节的能力。此外，还发现它们可以通过促进复极化来降低神经元兴奋性。而且，[植物名称未给出]油和乙醇提取物可重新平衡Treg/Th - 17细胞因子，将促炎/抗炎细胞因子和Treg标志物，例如FOXP3和CTLA - 4，恢复到正常水平。：目前的工作证实，[植物名称未给出]的提取物和精油具有不同的活性来改善组织病理学改变的进展。因此，当与其他AEDs联合使用时，[植物名称未给出]的提取物和精油可以减缓癫痫发生的进程。
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